Apoptosis and Cancer Chemotherapy Book

Foreword, Andrew H. Wyllie. Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents?, J. Martin Brown and Bradly G. Wouters. p53, Apoptosis, and Chemosensitivity, Scott W. Lowe. The Role of p53 in Chemosensitivity, Wafik S. El-Deiry. Function of the p53 Gene Family: A Holistic Perspective, Sandra J. Campbell, Mary O'Neill, and Peter A. Hall. Mismatch Repair Deficiency, Apoptosis, and Drug Resistance, Robert Brown. Involvement of the c-Abl Tyrosine Kinase in Apoptotic Response to Anticancer Agents, Zhi-Min Yuan, Surender Kharbanda, Ralph Weichselbaum, and Donald Kufe. Bcl-2 Family Proteins: Relative Importance as Determinants of Chemoresistance in Cancer, John C. Reed. Bax, A Death Effector Molecule: Its Role in Development and Oncogenesis, Yi-Te Hsu and Richard. Youle. Bax, A Proapoptotic Protein Forming Channels in Mihondria, Jean-Claude Martinou and Bruno Antonsson. Mechanism of Action of the Proapoptotic Gene Bak, Robin Brown. Killers or Clean-Up Crew: How Central are the Central Mechanisms of Apoptosis?, Douglas R. Green and Helen M. Beere. Role of CD95 (APO-1/Fas) System in Chemotherapy, Klaus-Michael Debatin. Insulin-Like Growth Factor-1 Receptor as a Target for Anticancer Therapy, Renato Baserga and Mariana Resnicoff. Drug Resistance and the Survival Niche: Survival Signals Combine to Suppress Drug-Induced Apoptosis in B-Lymphoma Cells, Sian T. Taylor and Caroline Dive. Chemotherapy, Tumor Microenvironment, and Apoptosis, Constantinos Koumenis, Nicholas Denko, and Amato J. Giaccia. Molecular Regulation and Therapeutic Implications of Cell Death in Prostate Cancer, Timothy J. McDonnell, Elizabeth M. Bruckheimer, Bjorn T. Gjertsen, Tsuyoshi Honda, and Nora M. Navone. Chemotherapy and Apoptosis in the Ovary: CancerTreatment Comes with a Price, Jonathan L. Tilly and Alan L. Johnson. Role of Bcl-2 Family Members in Homeostasis, in Toxicology in Normal Intestine, and for Prognosis of Colonic Carcinomas, D. Mark Pritchard. Apoptosis and Breast Cancer, Nancy E. Davidson, Hillary A. Hahm, and Deborah K. Armstrong. Role of Apoptosis in Human Neuroblastomas, Garrett M. Brodeur and Valerie P. Castle. Response of Testicular Tumors to Chemotherapy: Relative Role of Drug-DNA Interactions and Apoptosis, Christine M. Chresta. Concluding Remarks: Has the Information Explosion on Apoptosis Affected Clinical Practice?, Joseph R. Bertino. Index.