Trends in Gastroenterology and Hepatology Book

	Preface
	Contributors
	Reflecting Forward: Gastroenterology in the New Millennium	3
	Pathophysiology of and New Treatment for Ulcerative Colitis	15
	New Target of Gastroenterology: Overcoming Life Style-Related Diseases	27
	Examination of Cytotoxic T Lymphocyte-Mediated Apoptosis Pathway in Peptic Ulcer Formation with or without H. pylori Infection	35
	Epidermal Growth Factor Inhibits Helicobacter pylori Lipopolysaccharide-Induced Apoptosis of Primary Cultures of Gastric Pit Cells	43
	Impaired Sensitivity to Fas-Induced Apoptosis of Lymphocytes in Ulcerative Colitis Lesions	47
	Tumor Necrosis Factor [alpha]-Induced Hepatic Apoptosis and Hepatocyte Sensitization	53
	Molecular Mechanisms of D-Galactosamine/Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice and the Effects of Therapeutic Agents	59
	Ethanol-Induced Apoptosis Mediated by Mitochondrial Permeability Transition in Primary Cultured Sinusoidal Endothelial Cells	63
	Therapeutic Strategies for Hepatocellular Carcinoma Based on Analyses for Resistance to Apoptosis Mediated by Activation of Intracellular Signal Pathways	66
	Expression of Apoptosis-Related Factors in Human Pancreatic Duct Cell Carcinoma and Intraductal Papillary-Mucinous Tumor	71
	Effect of Exogenous and Endogenous Nitric Oxide on Endothelial Permeability Induced by Oxidants In Vitro	79
	Gastric Carcinoma and Helicobacter pylori Infection: Role of Nitric Oxide and Inflammatory Cytokines in Gastric Carcinogenesis	82
	Does Cyclooxygenase-2 Down-Regulate Gastric Inflammation?	86
	Regulation of Mucin Synthesis by Neuronal Nitric Oxide Synthase in Gastric Pit Cells	90
	Role of Nitric Oxide and Capsaicin-Sensitive Sensory Nerves in Gastric Receptive Relaxation and Adaptive Relaxation in Isolated Stomachs of Guinea Pigs	95
	Role of Inducible Nitric Oxide Synthase in Murine Colitis	99
	Role of Nitric Oxide in the Progression of Severe Acute Pancreatitis	103
	Role of Nitric Oxide in the Progression of Acute Pancreatitis	106
	Protective Effect of Nitric Oxide on Acute Liver Failure in Rats	112
	Regulatory Mechanism of Cationic Amino Acid Transporters in Hepatic Sinusoidal Ito Cells	115
	Novel NADPH Oxidase, Moxl, Expressed in Cultured Gastric Pit Cells: Modulation of NF-[kappa]B Activation	123
	Role of PPAR[gamma] in the Growth and Differentiation of Gastric and Colorectal Cancers	128
	PPAR[gamma] Ligand and Induction of Growth Arrest in Pancreatic Cancer Cells	132
	Role of [beta]-Catenin During Early Colorectal and Hepatic Carcinogenesis	138
	Growth Inhibition of Hepatoma Cells by Type 1 Interferons: Modification by Mutations in the Interferon Regulatory Factor-1 Gene	142
	Growth Inhibition of Pancreatic Cancer Cell Lines by Ligand Activation of Nuclear Hormone Receptors Through Up-Expression of WAF1/CIP1/p21	147
	Immunopathological Features of Granuloma Formation in the Intestinal Mucosa of Patients with Crohn's Disease	155
	Helicobacter pylori and N-Methyl-N'-nitro-N-nitrosoguanidine Induction of Dendritic Cell Infiltration of the Pyloric Mucosa of Mongolian Gerbils	160
	Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells	167
	Autoimmune Mechanisms of Cancer-Associated Paraneoplastic Syndromes: A Review	171
	Antitumor Activity Against Gastrointestinal and Hepatocellular Carcinoma Induced by Immunization with Fusion of Dendritic and Carcinoma Cells in Mice	175
	Essential Role for Interleukin-6 in the Pathogenesis of Crohn's Disease	173
	Activation of Nuclear Factor [kappa]B in Dextran Sulfate Sodium-Induced Colitis in Mice and Their Inhibition by Phenyl N-tert-Butylnitrone	187
	Essential Roles for Th2-Type Responses in Chronic Intestinal Inflammation	193
	Induction of Colitis and Exocrinopathy in Nude Mice Induced by Immunocompetent Cell Transfer from Murine Retrovirus-Infected Mice	197
	Potential Role of Mucosal Addressin Cell Adhesion Molecule-1 in Inflammatory Bowel Diseases	201
	Anti-Saccharmomyces cerevisiae Antibody in Inflammatory Bowel Disease	205
	Reactive Oxygen Species and Colonic Epithelial Cell Apoptosis in Ulcerative Colitis	208
	Effect of Antiulcer Drugs for Treatment of Nonsteroidal Antiinflammatory Drug-Induced Ulcers	215
	Role of Intravascular Neutrophils in the Pathogenesis of Aspirin-Induced Gastric Mucosal Injury	219
	Mucin Secretion Evoked by Prostaglandin E[subscript 2] in Guinea Pig Antral Mucous Cells: Role of EP1/EP4 Receptors	224
	Effects of Indomethacin and NS-398 on Acid-Induced E-Cadherin Surface Expression in Rat Gastric Epithelial Cells	229
	Roles of Reactive Nitrogen Species in Helicobacter-Related Carcinogenesis	233
	Interaction Between Helicobacter pylori Infection and NSAID Use	237
	Interrelations of Nonsteroidal Antiinflammatory Drugs, H. pylori Infection, and Gastric Damage	242
	Microvascular Leukocyte Activation and Apoptosis in Helicobacter pylori-Colonized Gastric Mucosa	249
	Alteration of Gastric Microcirculatory Achitecture During Healing of Acetic Acid-Induced Ulcer and Helicobacter pylori Infection	257
	Cyclooxygenase and Colon Cancer	263
	Contribution of Colon Cancer Cells to Mesenchymal Cells in the Formation of Hepatic Metastasis	267
	Hepatic Microcirculation in Massive Liver Necrosis and Liver Regeneration	272
	Prevention of Hepatic Ischemia/Reperfusion Injury by Microcirculatory Regulation: Application to Liver Transplantation	277
	Genetic Manipulation of Sinusoidal Endothelial Cells	283
	Controlling Tumor Microenvironment by the Antiangiogenesis Strategy	287
	Pancreatic Blood Flow in Chronic Alcoholic Pancreatitis	290
	The Role of Hepatic Oval Cells in Hepatic Regeneration: Possible Clinical Applications	297
	Hepatoma-Derived Growth Factor: Involvement in Liver Development and Regeneration	302
	Tumor Necrosis Factor and Liver Regeneration	306
	Heparin-Binding EGF-Like Growth Factor: Hepatotrophic Factor in Liver Regeneration	312
	Effects of Growth Stimulatory and Inhibitory Factors on Signal Transduction of Cultured Rat Hepatocyte and the Regulation of Cyclin D1 Transcription	317
	Significance of the Relation Between Hepatocyte Growth Factor and Transforming Growth Factor-[alpha] in Hepatocyte Proliferation	321
	Transcriptional Regulation of Type I Collagen Gene Expression by Transforming Growth Factor-[beta] and Smad Proteins	327
	Clinical Usefulness of Plasma MMP-9 Assay Compared with the Plasma MMP-2 Assay in Patients with Chronic Liver Disease	331
	Molecular Mechanisms of Matrix Metalloproteinase-1 Gene Expression in Hepatic Stellate Cells	336
	Molecular Analysis of Stellate Cells Activation by Proteomics	340
	Tissue Inhibitor of Metalloproteinase-1: Strong Promotion of Liver Fibrosis Development in the Transgenic Mouse Model	344
	Antioxidant and Antiapoptotic Activities of a Tissue-Specific Selective Estrogen Receptor Modulator, Idoxifene, in Rat Fibrotic Liver and Cultured Rat Hepatocytes	350
	Blockade of TGF[beta] Signaling: Prevention of Fibrosis/Dysfunction and Enhancement of Hepatocyte Regeneration in Injured Liver	356
	Protease Inhibitors: Suppression of Activation of Hepatic Stellate Cells by Inhibiting TGF[beta] Generation	361
	Plasma Transforming Growth Factor-[beta]1: A Useful Marker for Hepatic Fibrosis in Chronic Hepatitis C	364
	Key Word Index	367