Joint Destruction in Arthritis and Osteoporosis Book

	Cartilage destruction in arthritis and osteoarthritis
	Osteoarthritis in the human knee: A dynamic process of cartilage matrix degradation, synthesis and reorganization	3
	Experimental arthritis models in the study of the mechanisms of articular cartilage loss in rheumatoid arthritis	15
	Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model	27
	Mechanisms of cartilage destruction in joint inflammation	49
	Immunopathology
	Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy	63
	Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis	69
	In vitro and in vivo effects of proteoglycan fractions in adjuvant treated rats	75
	Are antibodies reactive with chondrocyte proteins enriched in synovial fluids of patients with rheumatoid arthritis?	81
	Joint loading and cartilage metabolism
	The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy	89
	Effects of long-term running exercise on canine femoral head articular cartilage	95
	Human and bovine articular cartilage loading measured with a new resistive sensor: Effects of protease degradation and osteoarthritis	101
	Cytokines and growth factors
	Possible role of IL-1 in arthritis: Effects of prostaglandins in the regulation of IL-1 synthesis and actions	109
	Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways	121
	Does TGF-[beta] protect articular cartilage in vivo?	127
	Human rheumatoid synovial cells (HRSC) in culture express TGF-[beta] receptors and are growth stimulated by the factor	133
	Variable TGF-[beta] receptor expression regulates TGF-[beta] responses of articular chondrocytes	139
	Proteases and their inhibitors
	Proteolytic degradation in human articular cartilage: Its relationship to Stromelysin	149
	The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators	161
	The role of alpha-1-protease inhibitor (A1PI) in the inhibition of protease activity in human knee osteoarthritis	167
	Recombinant human protease nexin-1 prevents articular cartilage-degradation in the rabbit	173
	Therapeutic modulation of destruction
	In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes	181
	Animal models of early osteoarthritis: Their use for the evaluation of potential chondroprotective agents	195
	The in vivo effects of Naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism	207
	Interleukin-1 and Naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC)	213
	Effect of Rumalon (glycosaminoglycan-peptide) on the articular tissue	219
	Doxycycline protects serum alpha-1-antitrypsin from human neutrophil collagenase
	In vitro construction of cells-containing implants for articular cartilage regeneration	231
	Cellular aspects on treatment of cartilage injuries	237
	Human meniscus transplantation	243
	Methodology
	In situ hybridisation for Decorin mRNA in rabbit synovium during antigen-induced arthritis	249
	Osteoarthritis in rhesus macaques: Assessment of cartilage matrix quality by quantitative magnetic resonance imaging	255
	A magnetic resonance imaging study of joint degeneration in the guinea pig knee	261
	Development of immortalized human articular cartilage cell lines	267
	Subject Index	273