Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis & Health Book

	Introduction to Cytochrome P450	1
	General Aspects of NADPH Cytochrome P450 Reductase and Cytochrome b5	21
	Interaction Between Cytochrome P450 and Reductase	47
	Molecular Biology of Cytochrome P450: Evolution, Structure and Regulation	65
	The Role of Nuclear Receptors in the Regulation of P450s and Other Genes by Peroxisome Proliferators	87
	Mapping Determinants of the Substrate Specificities of P450s by Site-Directed Mutagenesis	105
	Diversity and Regulation of Cytochromes P450 in Aquatic Species	135
	Cytochrome P450 Expression in Rainbow Trout: An Overview	159
	Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity	181
	Problems Associated with Assessment of the Contribution of Individual Forms of Cytochrome P450 to the Metabolism of Xenobiotics	193
	Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function	209
	Flavin-Containing Monooxygenases: Substrate Specificity and Complex Metabolic Pathways	225
	Developmental Regulation of Biotransformation of Drugs and Other Xenobiotics	237
	Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical	249
	Mechanisms of Mutagenicity and Tumour Formation	261
	Genotoxicity Assays	303
	Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals	397
	Significance of Posttranslational Modification of Drug Metabolizing Enzymes by Phosphorylation for the Control of Carcinogenic Metabolites	411
	The Construction of Cell Cultures Genetically Engineered for Metabolic Competence towards Xenobiotics	429
	In Vitro Systems as Analytical Tools for Understanding and Predicting Drug Metabolism In Vivo	455
	The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides	461
	Metabolism of Xenobiotic Proestrogens and Estrogens by Cytochrome P450	479
	Metabolism of Antiestrogenic Anti-Cancer Agents by Cytochrome P450 and Flavin-Containing Monooxygenases. Mechanism of Action Involving Metabolites	491
	Therapeutic Agents and Cytochrome P450	503
	Drug Metabolism, Lipid Peroxidation and Glutathione	515
	Health Environment of Altai Territory and Monooxygenase and Conjugating Activities in Placentae of Newborn	533
	Monooxygenase Measurements as Indicators of Pollution in the Field	549
	Biochemical and Genotoxicological Monitoring of Ecosystems with Special Reference to Lake Baikal and Northern Black Sea	567
	Relating Biochemical Responses to "Higher Order" Effects	591
	List of Invited Contributors	605
	Index	607