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MAPK kinase kinase regulation of SAPK/JNK pathways Lisa Stalheim Gary L. Johnson 1
Abstract 1
Introduction 1
Organization of the MKKK-MKK4/7-JNK1/2/3 signaling module 3
MKKKs as signaling hubs controlling JNK activation 4
MLKs (mixed lineage kinases) 5
MEKKs (MAPK-ERK kinase kinases) 5
ASK1 (apoptosis signal-regulating kinase 1) 6
TAK1 (TGF[beta]-activated kinase 1) 6
TAO1 (thousand and one-amino acid kinase 1) 6
Insight into the function of MKKKs regulating the JNK pathway from targeted gene knockouts 7
MEKK1 7
MEKK2 8
MEKK4 9
ASK1 9
TAK1 10
MLK3 10
Conclusions 10
References 11
Alternative p38 MAPK pathways Francisco Inesta-Vaquera Guadalupe Sabio Yvonne Kuma Ana Cuenda 17
Abstract 17
Introduction 17
The p38[gamma] and p38[delta] MAPK pathways 19
p38[gamma] and p38[delta] substrates 20
Biological roles of p38[gamma] and p38[delta]MAPK pathways 21
Cell cycle and cellular transformation 21
Cellular differentiation 22
Cytoskeletal organization 24
More alternative p38MAPK pathways? 25
Concluding remarks 25
Acknowledgments 26
References 26
The regulation of stress-activated MAP kinase signalling by protein phosphatases Stephen M. Keyse 33
Abstract 33
Introduction 33
Regulation of stress-activated MAPKs by protein phosphatases in S. cerevisiae 34
Regulation of JNK and p38 MAPKs in Drosophila and C. elegans 37
The Drosophila phosphatase puckered plays key roles in development, stress responses and ageing 37
The vhp-1 phosphatase plays key roles in regulating stress responses and immunity in C. elegans 37
Mammalian MKPs play essential roles in the regulation of both JNK and p38 MAP kinase signalling 39
A subset of mammalian MKPs can regulate stress-activated MAPK pathways 39
DUSP10/MKP-5 plays a key role in adaptive and innate immunity 39
Inducible nuclear MKPs play key roles in stress resistance, immune function, and metabolic homeostasis 41
DUSP1/MKP-1 is a key regulator of stress resistance 41
DUSP1/MKP-1 regulates both immune and metabolic function 42
DUSP2/PAC-1 is a positive regulator of certain inflammatory responses 43
Summary 44
Acknowledgements 45
References 45
Transcriptional regulation by the p38 MAPK signaling pathway in mammalian cells Eusebio Perdiguero Pura Munoz-Canoves 51
Abstract 51
Transcription in mammalian cells 51
Regulatory DNA elements 52
Chromatin modifying activities 52
Transcription factors 52
The p38 MAPK signaling pathway 53
MAPK pathways 53
p38 MAPKs 53
Upstream kinases 53
Downstream substrates 54
Downregulators 57
Consequences of p38 MAPK activation on growth and differentiation of mammalian cells 57
Skeletal muscle proliferation and differentiation 58
Adipocyte differentiation 61
Cardiomyocyte hypertrophy 65
Conclusions and perspectives 68
Acknowledgements 70
References 70
Regulation of gene expression in response to osmostress by the yeast stress-activated protein kinase Hog1 Eulalia de Nadal Francesc Posas 81
Abstract 81
Introduction 81
Regulation of HOG signaling 82
The Hog1 MAPK as a central component of transcription activation upon osmostress 84
Transcriptional regulators downstream of the HOG pathway 84
The bZIP protein Sko1 85
The MADS box protein Smp1 85
The zinc finger proteins Msn2 and Msn4 86
The Hot1 transcription factor 86
Hog1 is part of the transcription complexes at the promoters of osmostress genes 87
Regulation of chromatin remodeling by the Hog1 MAPK 88
Hog1 MAPK and transcription elongation 89
Conclusions and perspectives 90
Acknowledgement 92
References 92
Regulation of tumorigenesis by p38[alpha] MAP kinase Ignacio Dolado Angel R. Nebreda 99
Abstract 99
Introduction 99
Cell cycle regulation 100
Inhibition of the G1/S transition 101
Inhibition of the G2/M transition 101
Stimulation of cell cycle progression 103
Regulation of cell survival and apoptosis 104
Apoptosis induction 107
Anti-apoptotic roles 108
Reconciling pro- and anti-apoptotic functions 110
Regulation of cell differentiation 111
Inflammation 112
Cell migration and invasion 113
Concluding remarks 114
Acknowledgments 115
References 115
List of abbreviations 128
Control of cell cycle by SAPKs in budding and fission yeast Sandra Lopez-Aviles Rosa M. Aligue 129
Abstract 129
Introduction 129
Cell cycle control by SAPKs in Saccharomyces cerevisiae 130
Cell cycle regulation 130
Stress-activated protein kinase pathway and cell cycle control 130
Cell cycle control by SAPKs in Schizosaccharomyces pombe 132
Cell cycle regulation 132
Stress-activated protein kinase pathway and cell cycle control 133
Concluding remarks 136
Acknowledgements 137
References 137
Hog1-mediated metabolic adjustments following hyperosmotic shock in the yeast Saccharomyces cerevisiae Bodil Nordlander Marcus Krantz Stefan Hohmann 141
Abstract 141
Yeast osmoregulation and carbon metabolism 141
Osmolytes: glycerol and trehalose as cell protectants 144
Flux control and potential direct effects on metabolism by Hog1: PFK2 147
Glycerol export and import 151
Integration: a potential timeline of adjustments under osmo-stress 153
Acknowledgements 153
References 153
Control of mRNA stability by SAPKs Miguel A. Rodriguez-Gabriel Paul Russell 159
Abstract 159
Introduction 159
Eukaryotic mRNA turnover 160
Proteins involved 160
Localization 161
mRNA cis acting elements 162
Control of mRNA stability by SAPKs 162
RNA binding proteins involved in SAPK regulation of mRNA stability 163
Concluding remarks 165
Acknowledgement 166
References 166
Intrinsically active (MKK- independent) variants of SAPKs - How do they work? Inbal Maayan David Engelberg 171
Abstract 171
Introduction 171
Intrinsically active variants of SAPKs - bypassing their natural mode of activation 173
Mechanism of activation of native SAPKs and of intrinsically active SAPKs 176
The role of the phosphoacceptors in the intrinsically active variants 176
The mutants acquired an auto-phosphorylation capability 178
Structural changes due to activation 179
Discussion 180
References 182
Regulation of MAPK signaling in yeast Fabian Rudolf Serge Pelet Matthias Peter 187
Abstract 187
Introduction to MAPK signaling during mating and high osmolarity conditions in yeast 187
Quantifying signaling at the single cell level 189
Regulation of mating signaling 191
Pathway activation 191
Spatial/temporal regulation 193
Regulation of mating signaling by internal and external factors 196
The Osmotic stress pathway 197
Pathway activtion by stress signals 197
Internal regulation of the HOG pathway 198
Specificity/crosstalk between the two pathways 199
General principles for yeast MAPK regulation 199
Single cell measurement - future research 200
Acknowledgments 201
References 201
Modeling the dynamics of stress activated protein kinases (SAPK) in cellular stress response Edda Klipp Jorg Schaber 205
Abstract 205
Introduction 205
Mathematical modeling in systems biology 206
Purpose of modeling 206
Model development in five steps 206
Mathematical modeling of biochemical reaction networks 209
Analysis of models 212
Studied phenomena 214
Dynamic behavior and parameters 214
Ultrasensitivity, amplification, and robustness 216
Relative importance of kinases and phosphatases 217
Regulation of MAPK cascade by receptor activity 218
Regulation of MAPK cascade by downstream processes - feedback 219
Crosstalk and dynamics 220
Discussion/Summary 221
Acknowledgement 221
References 222
Stress-activated protein kinase signaling in Drosophila Gerasimos P. Sykiotis Dirk Bohmann 225
Abstract 225
Introduction 225
Structural conservation of the JNK and p38 pathways in Drosophila 226
JNK signaling in Drosophila 228
Morphogenesis, wound healing, and immunity 228
Oxidative stress defense and lifespan regulation 229
JNK-dependent apoptosis during development 229
JNK in TNF- and irradiation-induced apoptosis 230
p38 signaling in Drosophila 232
Identification of the fruit fly p38 homologues 232
p38 in Drosophila development 232
Genetic analysis of the fruit fly p38 pathway 234
RNA interference in cultured Drosophila cells 235
Downstream effectors and upstream components of Drosophila p38 signaling 236
Outlook 237
References 237
Protein kinases as substrates for SAPKs Alexey Kotlyarov Matthias Gaestel 243
Abstract 243
Definition of kinases downstream to SAPKs 243
Primary structure and overview 245
SAPK-regulated kinases in detail 245
MSKs 245
MNKs 248
MK2/3 251
Summary and Perspectives 253
Acknowledgement 253
References 253
List of abbreviations 260
Functions of stress-activated MAP kinases in the immune response Mercedes Rincon Roger J. Davis 261
Abstract 261
Introduction 261
SAPK Functions in macrophages and dendritic cells 261
Role of JNK 261
Role of p38 MAPK 263
SAPK functions in B cells 264
Role of JNK 264
Role of p38 MAPK 264
SAPK Functions in T cell development 265
Role of JNK 265
Role of p38 MAPK 265
SAPK functions in CD4[superscript +] T cells 266
Role of JNK 266
Role of p38 MAPK 268
SAPK functions in CD8[superscript +] T cells 269
Role of JNK 269
Role of p38 MAPK 271
SAPK functions in other T cell populations 272
SAPK functions during an in vivo immune response 273
Concluding remarks 275
References 275
Stress-activated MAP kinases in chromatin and transcriptional complexes Nicholas T. Crump Ya Ting Han Louis C. Mahadevan 283
Abstract 283
Introduction 283
SAPK cascades in yeast and mammals 284
Phosphorylation of sequence-specific transcription factors and recruitment of histone-modifying enzymes 286
Phosphorylation of general transcription factors 288
Phosphorylation of nucleosomal proteins 288
Inducible histone H3 phosphorylation is mediated by MSK1/2 289
Molecular function of histone H3 phosphorylation 290
SAPKs may also act independently of their kinase activity 291
A role for mammalian SAPKs in transcriptional and elongation complexes? 293
Concluding remarks 293
References 294
SAPK and translational control Malin Hult Per Sunnerhagen 299
Abstract 299
Background and paradigms for control of translation 299
Global controls of translation 300
Global control of initiation by phosphorylation of eIF2[alpha] 300
Global control of initiation by phosphorylation of eIF4E/4E-BP 300
Global control of elongation 301
Individual control of mRNA species - AREs 302
ARE-binding proteins under SAPK control 303
MAPK-activated protein kinases in signalling through AREs 303
Links between translation and mRNA degradation 304
IRES 304
Indirect effects on translation through transcriptional and posttranscriptional regulation 305
Concluding remarks 306
Acknowledgements 307
References 307
Index 311
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Add Stress-Activated Protein Kinases, To maximize the probability of survival, cells need to coordinate their intracellular activities in response to changes in the extracellular environment. MAP kinase cascades play an important role in the transduction of signals inside eukaryotic cells. In, Stress-Activated Protein Kinases to the inventory that you are selling on WonderClubX
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Add Stress-Activated Protein Kinases, To maximize the probability of survival, cells need to coordinate their intracellular activities in response to changes in the extracellular environment. MAP kinase cascades play an important role in the transduction of signals inside eukaryotic cells. In, Stress-Activated Protein Kinases to your collection on WonderClub |