Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists Book

Preface.

Nomenclature.

Part I Basic Concepts and Principles.

1 Introduction.

1.1 Background and Scope.

1.2 Dimensions and Units.

1.3 Intensive and Extensive Properties.

1.4 Equilibria and Rates.

1.5 Batch versus Continuous Operation.

1.6 Material Balance.

1.7 Energy Balance.

References.

2 Elements of Physical Transfer Processes.

2.1 Introduction.

2.2 Heat Conduction and Molecular Diffusion.

2.3 Fluid Flow and Momentum Transfer.

2.4 Laminar versus Turbulent Flow.

2.5 Transfer Phenomena in Turbulent Flow.

2.6 Film Coefficients of Heat and Mass Transfer.

References.

3 Chemical and Biochemical Kinetics.

3.1 Introduction.

3.2 Fundamental Reaction Kinetics.

References.

4 Cell Kinetics.

4.1 Introduction.

4.2 Cell Growth.

4.3 Growth Phases in Batch Culture.

4.4 Factors Affecting Rates of Cell Growth.

4.5 Cell Growth in Batch Fermentors and Continuous Stirred-Tank Fermentors (CSTF).

References.

Part II Unit Operations and Apparatus for Bio-Systems.

5 Heat Transfer.

5.1 Introduction.

5.2 Overall Coefficients U and Film Coefficientsh.

5.3 Mean Temperature Difference.

5.4 Estimation of Film Coefficientsh.

5.5 Estimation of Overall Coefficients.

References.

6 Mass Transfer.

6.1 Introduction.

6.2 Overall Coefficients k and Film Coefficients k of Mass Transfer.

6.3 Types of Mass Transfer Equipment.

6.4 Models for Mass Transfer at the Interface.

6.5 Liquid-Phase Mass Transfer with Chemical Reactions.

6.6 Correlations for Film Coefficients of Mass Transfer.

6.7 Performance of Packed Columns.

References.

7 Bioreactors.

7.1 Introduction.

7.2 Some Fundamental Concepts.

7.3 Bubbling Gas–Liquid Reactors.

7.4 Mechanically Stirred Tanks.

7.5 Gas Dispersion in Stirred Tanks.

7.6 Bubble Columns.

7.7 Airlift Reactors.

7.8 Packed-Bed Reactors.

7.9 Microreactors.

References.

8 Membrane Processes.

8.1 Introduction.

8.2 Dialysis.

8.3 Ultrafiltration.

8.4 Microfiltration.

8.5 Reverse Osmosis.

8.6 Membrane Modules.

References.

9 Cell–Liquid Separation and Cell Disruption.

9.1 Introduction.

9.2 Conventional Filtration.

9.3 Microfiltration.

9.4 Centrifugation.

9.5 Cell Disruption.

References.

10 Sterilization.

10.1 Introduction.

10.2 Kinetics of the Thermal Death of Cells.

10.3 Batch Heat Sterilization of Culture Media.

10.4 Continuous Heat Sterilization of Culture Media.

10.5 Sterilizing Filtration.

References.

11 Adsorption and Chromatography.

11.1 Introduction.

11.2 Equilibria in Adsorption.

11.3 Rates of Adsorption into Adsorbent Particles.

11.4 Single- and Multi-Stage Operations for Adsorption.

11.5 Adsorption in Fixed Beds.

11.6 Separation by Chromatography.

References.

Part III Practical Aspects in Bioengineering.

12 Fermentor Engineering.

12.1 Introduction.

12.2 Stirrer Power Requirements for Non-Newtonian Liquids.

12.3 Heat Transfer in Fermentors.

12.4 Gas–Liquid Mass Transfer in Fermentors.

12.5 Criteria for Scaling-Up Fermentors.

12.6 Modes of Fermentor Operation.

12.7 Fermentors for Animal Cell Culture.

References.

13 Downstream Operations in Bioprocesses.

13.1 Introduction.

13.2 Separation of Microorganisms by Filtration and Microfiltration.

13.3 Separation by Chromatography.

13.4 Separation in Fixed Beds.

13.5 Sanitation in Downstream Processes.

References.

14 Medical Devices.

14.1 Introduction.

14.2 Blood and Its Circulation.

14.3 Oxygenation of Blood.

14.4 Artificial Kidney.

14.5 Bioartificial Liver.

References.

Appendix.

Index.