|
|
Sold Out
Book Categories |
Preface.
List of Contributors.
Color Plates.
Section A: Molecular Aspects, Introduction and Purification.
1 Type I Interferons: Genetics and Structure (Shamith A. Samarajiwa, William Wilson and Paul J. Hertzog).
1.1 Introduction.
1.2 The Type I IFN Genetic Locus.
1.3 Type I IFN Genes.
1.4 Type I IFN Gene-regulatory Regions.
1.5 Evolution of the Type I IFNs.
1.6 Natural and Induced Mutations in IFN Genes.
1.7 Secondary Structural Features of Type I IFNs.
1.8 The Structure of Type I IFNs.
2 Activation of Interferon Gene Expression Through Toll-like Receptor-dependent and -independent Pathways (Peyman Nakhaei, Suzanne Paz and John Hiscott).
2.1 Introduction.
2.2 IFN-β Gene Transcription.
2.3 IRF Family Members.
2.4 Role of IRFs in Virus-mediated IFN Activation.
2.5 IFN Signaling Pathways.
2.6 Conclusions.
3 Interferon Proteins: Structure, Production and Purification (Dimitris Platis and Graham R. Foster).
3.1 Introduction.
3.2 The Structure of Type I IFNs.
3.3 Production and Purification of Type I IFNs.
3.4 Long-acting IFNs.
3.5 Summary.
4 Interferon-g: Gene and Protein Structure, Transcription Regulation, and Actions (Ana M. Gamero, Deborah L. Hodge, David M. Reynolds, Maria Cecilia Rodriguez-Galan, Mansour Mohamadzadeh and Howard A. Young).
4.1 Introduction.
4.2 IFN-γ Gene Structure and Regulation.
4.3 IFN—γ Signal Transduction.
4.4 IFN—γ in Th Cell Development.
4.5 IFN—γ and DCs.
4.6 IFN—γ – Role in Tumor Development and Growth.
4.7 Summary.
5 Interferon and Related Receptors (Sidney Pestka and Christopher D. Krause).
5.1 Introduction.
5.2 IFNs and IFN-like Molecules in Brief.
5.3 The Receptors.
5.4 The Type I IFN Receptor.
5.5 The Type II IFN (IFN-g) Receptor.
5.6 The IL-28R1 and -10R2 Receptor Complex.
5.7 Overview of Multichain Receptors.
5.8 Global Summary.
6 Type III Interferons: The Interferon-l Family (Sergei V. Kotenko and Raymond P. Donnelly).
6.1 Introduction.
6.2 The Class II Cytokine Receptor Family (CRF2) and their Ligands.
6.3 Genomic Structure.
6.4 Receptor Complex and Signaling.
6.5 Biological Activities.
6.6 The Murine IFN-l Antiviral System.
6.7 Evolution of the IFN Family.
6.8 Therapeutic Potential.
6.9 Conclusions.
Section B: Biological Properties.
7 Biological Actions of Type I Interferons (Melissa M. Brierley, Jyothi Kumaran and Eleanor N. Fish).
7.1 Introduction.
7.2 Sources of Type I IFN Production and Secretion.
7.3 Type I IFN Interactions with the Receptor Complex.
7.4 Type I IFN-induced Signaling Cascades.
7.5 IFN-inducible Biological Responses.
7.6 Summary.
8 Interferons and Apoptosis – Recent Developments (Michael J. Clemens and Ian W. Jeffrey).
8.1 Introduction.
8.2 The Role of IFN-regulated Genes in the Control of Apoptosis.
8.3 The Protein Kinase PKR and the Phosphorylation of Polypeptide Chain Initiation Factor eIF2α.
8.4 IFNs and the Apoptotic Effects of TRAIL.
8.5 Signal Transduction Pathways for IFN-mediated Effects on Apoptosis.
8.6 The Antiapoptotic Effects of IFNs.
8.7 Conclusions.
9 Viral Defense Mechanisms against Interferon (Santanu Bose and Amiya K. Banerjee).
9.1 Introduction.
9.2 Innate Immune Antiviral Defense Mechanisms of Host Cells.
9.3 Evasion of IFN-mediated Antiviral Response.
9.4 Concluding Remarks.
Section C: Clinical Applications.
10 Overview of Clinical Applications of Type I Interferons (Frank Müller).
10.1 Introduction.
10.2 Biological Effects.
10.3 Type I IFN Products Currently Available or Under Development.
10.4 Pharmacokinetics.
10.5 Clinical Applications of Type I Interferons.
10.6 IFN Toxicity.
10.7 Type I IFNs in the Future.
11 Clinical Applications of Interferon-γ (Christine W. Czarniecki and Gerald Sonnenfeld).
11.1 Introduction.
11.2 IFN-γ – The Molecule.
11.3 FDA-approved Indications: Established Benefit and Risks.
11.4 Infectious Diseases.
11.5 Infection Following Serious Trauma.
11.6 Atopic Dermatitis (AD).
11.7 Idiopathic Pulmonary Fibrosis (IPF).
11.8 Systemic Sclerosis (SSc).
11.9 Radiation-induced Fibrosis.
11.10 Chronic Hepatitis.
11.11 Oncology Indications: Ovarian Cancer.
11.12 Conclusions.
Section D: Measurement of Interferons and Anti-Interferons.
12 Measurement of Interferon Activities (Tony Meager).
12.1 Introduction.
12.2 The IFNs: Mechanisms of Action, Protein Induction and Biological Activities.
12.3 Measurement of Biological Activities of IFNs.
12.4 Regulatory Landscape.
13 The Development and Measurement of Antibodies to Interferon (Sidney E. Grossberg and Yoshimi Kawade).
13.1 Introductory Perspective.
13.2 NAbs.
13.3 Immunoassays for Non-NAbs.
13.4 Epitope Analysis.
13.5 Development of Antibodies during IFN Therapy.
13.6 Summary.
Index.
| Price | Condition | Delivery | Seller | Action |
| $99.99 | Digital |
| WonderClub |
Julia Cole
reviewed The Interferons: Characterization and Application on March 29, 2016
The Interferons
The book opens with the mass poisoning of thousands of people in Bangladesh by drinking water contaminated with arsenic. This book has a very important current environmental message for all of us because environmental arsenic is not just a problem facing Bangladesh. There is a USGS map on page 161 showing the states in the U.S. where acquifers used for drinking water contain dangerously high levels of arsenic. As a cancer patient, I have often wondered why I keep meeting people who are being treated for cancer but are in none of the high-risk groups. I was surprised to read in this book that years of exposure to water contaminated with non-lethal levels of arsenic causes lung cancer. Unfortunately, this surprising information is floating around in a hodge-podge of history and unrelated anecdotes.
I would have assumed that a major publishing company like Macmillan still employed editors in 2005 but, apparently, I was wrong. The author is obviously extremely knowledgeable, and the separate topics he addresses are all interesting but the book is totally disjointed.
I imagine that the author wrote a long academic article addressing the arsenic contaminated well water in Bangladesh, a medium length exposé on the history and ethics of William Morris & Company. Someone remarked "You have almost enough material for a book." The author tossed in a short popular article on the worldwide problem of environmental arsenic, and several short sensational anecdotes about murders committed using arsenic and mailed the separate articles to Macmillan. His publisher dropped the articles on the floor, told an intern to put them back in order and then published them.
Login|Complaints|Blog|Games|Digital Media|Souls|Obituary|Contact Us|FAQ
CAN'T FIND WHAT YOU'RE LOOKING FOR? CLICK HERE!!! X
You must be logged in to add to WishlistX
This item is in your Wish List
X
This item is in your Collection
The Interferons: Characterization and Application
X
This Item is in Your Inventory
The Interferons: Characterization and Application
X
You must be logged in to review the productsX
X
X
Add The Interferons: Characterization and Application, At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Ed, The Interferons: Characterization and Application to the inventory that you are selling on WonderClubX
X
Add The Interferons: Characterization and Application, At long last, the first book to cover all important areas of interferon science in one volume. Top scientists, including many pioneers in the field, highlight the role of interferons as research tools and as therapeutic agents in clinical applications. Ed, The Interferons: Characterization and Application to your collection on WonderClub |