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Acknowledgements xi
Introduction xiii
Diabetes Mellitus 1
Introduction 1
Blood Glucose Values in Birds 2
Do Birds Suffer Adverse Consequences from a High Blood Glucose Concentration 5
Anatomic and Physiologic Design Features 6
Concluding Remarks and Future Research 26
References 31
Chronic Renal Failure 40
Introduction 40
Metabolic Rate and Renal Function 42
Nitrogen and Urea Metabolism and Protein Turnover 44
Additional Aspects of Renal Failure 56
Natural Animal Model 57
Bear and Small Mammal Hibernators 64
Concluding Remarks and Future Directions 66
References 70
Atherosclerotic Vascular Disease 78
Introduction 78
Atherosclerosis in Mammals 79
Biology of the Arterial System: Implications for the Genesis of Atherosclerosis in Mammals 83
Genesis of Atherosclerotic Lesions 88
Natural Animal Model: The Fish 89
Fish Coronary Circulation 90
Fish Coronary Artery Thickenings 91
Genesis of Fish Lesions 94
Biomechanical Factors in Fish 94
Dietary Influences and Role of Cholesterol in Fish 96
Biology of the Vascular Smooth Muscle in Fish 99
Concluding Remarks: What Can We Learn From the Fish as a Natural Model? 99
References 102
Disuse Osteoporosis and Disuse Muscle Atrophy 107
Disuse Osteoporosis 108
Disuse Muscle Atrophy 126
References 143
Ammonia Toxicity 149
Ammonia Tolerance and Metabolism 149
Brain Ammonia Metabolism 157
Glutamatergic Neurons 159
Glutamate, a Neurotransmitter and the "Glutamate-Glutamine" Cycle 160
Mechanism of Ammonia Neurotoxicity 164
Effects on Brain Energy Metabolism 169
Effects on Glutamatergic Synapses 171
Ammonia and the Fish Central Nervous System 175
Summary 181
References 183
Hypoxia/Ischemia 190
Cerebral Blood Flow: Its Regulation 191
Brain Energy Metabolism 195
Oxygen and Oxygen/Glucose Deprivation and the Brain 199
Natural Animal Models 230
Concluding Remarks and Future Directions 245
References 254
Epilogue 261
References 266
Index 267
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Charles Lewis
reviewed Comparative Physiology, Natural Animal Models and Clinical Medicine: Insights into Clinical Medicine from Animal Adaptations on October 15, 2018
Comparative Physiology, Natural Animal Models and Clinical Medicine
Very nice read. Describes the often tumultuous political scene that underlay the Human Genome Sequencing project.
Originally the Human Genome project was publicly funded, and included many of the brightest human geneticists in the world. In addition to being brilliant scientists, this group contained some fascinating personalities. The author does an excellent job of conveying these often extreme personalities and setting the scene for what would eventually escalate into the scientific equivalent of all out nuclear war.
The story really gets interesting when a rogue geneticist name J. Craig Venter decides to leave the public consortium and join a corporate venture with the intention of beating the public scientists to the prize. Most of the book tracks Venter and story. He is a fascinatingly conflicted character, equal parts megalomaniac and saint.
The book delves into the science in an approachable manner. This is pretty interesting in its own right, but the real story is the brinksmanship between the public and private sequencing groups.
Overall if you are interested in learning about human genomics and like a battle of the titans plot line this is the book for you
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