Clinical Trials in Neurology Book

1	Ethical Considerations	3
2	Assessment Measures and Clinical Scales	17
3	Ethics, Outcome Variables and Clinical Scales: The Clinician's Point of View	29
4	The Cochrane Collaboration Reviews in Neurology	43
5	Drug Development Stages	53
6	Drug Regulatory Requirements in the United Kingdom and Europe	59
7	Drug Regulatory Requirements in the United States	71
8	Quality Control and Data Monitoring: A Guide To Good Clinical Practice	81
9	Statistical Issues in Clinical Trials in Neurology	95
10	Analysis of Results: Statistical Principles	105
11	Survival Analysis	121
12	The Intention-to-Treat Principle for Clinical Trials	131
13	Statistical Analysis of Repeated-Measures Data with Drop-outs	145
14	The Role of Meta-analyses in Clinical Research: Uses and Limitations	157
15	Outcome Variables in Dementia Trials: Conceptual and Practical Issues	171
16	Dementia: Trial Design and Experience with Large Multicentre Trials	183
17	Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls	199
18	Clinical Trials in Stroke Prevention in North America	213
19	Cerebrovascular Disease: Experience Within Large Multicentre Trials	229
20	Epilepsy: Ethics, Outcome Variables and Clinical Scales	251
21	Epilepsy: Basic Designs, Sample Sizes and Experience with Large Multicentre Trials	261
22	Headache: Ethics, Outcome Variables and Clinical Studies	271
23	Headache: Basic Trial Designs, Sample Sizes and Pitfalls	279
24	Headache: Experience with Large Multicenter Trials in the Treatment of Migraine Attacks	291
25	Parkinson's Disease: Outcome Variables and Clinical Scales	299
26	Parkinson's Disease: A Review of Drug Trials	311
27	Parkinson's Disease: Experience with Large Multicentre Trials	325
28	Tremor: Clinical Measurement of Impairment, Disability and Handicap	339
29	Tremor: Natural Behaviour, Trial Design and Physiological Outcome Measures	347
30	Multiple Sclerosis: Ethics, Outcome Variables and Clinical Scales	359
31	Multiple Sclerosis: Study Design, Sample Sizes and Pitfalls	371
32	Multiple Sclerosis: Experience with Large Clinical Trials	387
33	Motor Neurone Disease: Ethics, Outcome Variables and Clinical Scales	403
34	Motor Neurone Disease: Basic Designs, Sample Sizes and Pitfalls	427
35	Motor Neurone Disease: Experience with Large Multicentre Trials	451
36	Peripheral Neuropathies: Controlled Clinical Trials	465
37	Peripheral Neuropathies: Experience with Large Multicentre Trials	479
38	Disorders of the Neuromuscular Junction: Outcome Measures and Clinical Scales	485
39	Myasthenia Gravis: Basic Designs, Sample Sizes and Pitfalls	501
40	Myopathies: Ethics, Outcome Variables and Clinical Scales	505
41	Myopathies: Basic Designs, Sample Sizes and Pitfalls	515
	Index	529