The Diabetic Kidney Book

Part I: Basic Pathophysiology and Biochemistry of Diabetic Nephropathy

A. Pathophysiology

Angiotensin II and Its Receptors in the Pathogenesis of Diabetic Nephropathy

David J. Leehey, Ashok K. Singh, and Rekha Singh

Altered Renal Microvascular Function in Early Diabetes

Pamela K. Carmines, Joseph P. Bast, and Naohito Ishii

B. Interstitial Disease

Proteinuria and Interstitial Fibrogenesis in Diabetic Nephropathy

Raimund Hirschberg

C. Podocytes

Podocytes and Diabetic Nephropathy

George Jerums, Sianna Panagiotopoulos, and Richard MacIsaac

D. Altered Metabolic Pathways

Altered Glucose Transport and Its Metabolic Effects in Glomerular Cells

Charles W. Heilig

mRNA Translation in Diabetic Nephropathy

Balakuntalam S. Kasinath, Myung Ja Lee, Denis Feliers, and Nahum Sonenberg

The Hexosamine Biosynthesis Pathway: Contribution to the Pathogenesis of Diabetic Nephropathy

I. George Fantus, Howard J. Goldberg, Catharine I. Whiteside, and Delilah Topic

E. Nonenzymatic Glycosylation

Glycation: Receptor for Advanced Glycation Endproducts and Diabetic Nephropathy

Vivette D'Agati and Ann Marie Schmidt

F. Oxidative Stress

Oxidative and Glycooxidative Stress in Diabetic Nephropathy

Frederick R. DeRubertis and Patricia A. Craven

G. Growth Factors

Connective Tissue Growth Factor in the Pathogenesis of Diabetic Nephropathy: A Target for Therapeutic Intervention

Bruce L. Riser, Alessia Fornoni, and Sujatha Karoor

Vascular Endothelial Growth Factor as a Determinant of Diabetic Nephropathy

Geoffrey Boner and Mark E. Cooper

Transforming Growth Factor-b Signal Transduction in the Pathogenesis of Diabetic Nephropathy: Identifying Molecular Targets for Therapeutic Intervention

Sheldon Chen and Fuad N. Ziyadeh

H. New Approaches to the Study of Diabetic Nephropathy

Hepayte Growth Factor: Physiological and Therapeutic Ligand to Attenuate Diabetic Nephropathy

Shinya Mizuno and Toshikazu Nakamura

Proteomics in the Investigation of Diabetic Nephropathy

Visith Thongboonkerd

Gene Expression Profiling in the Investigation of Diabetic Nephropathy

Katalin Susztak, Erwin Bottinger, and Kumar Sharma

PPAR-g Ligands and Diabetic Nephropathy

Keiji Isshiki, Daisuke Koya, and Masakazu Haneda

a-Endosulfine in Diabetic Nephropathy

Jerry Yee and Balazs Szamosfalvi

The Prospect of a Novel Therapeutic, Bone Morphogenetic Protein-7, in Diabetic Nephropathy

Keith A. Hruska, Laura DePetris, Tingting Li, Song Wang, Theresa Geurs, Frank Strebeck, Qing Chen, and Helen Liapis

Part II: Clinical Aspects of Diabetic Nephropathy

A. Genetics and Risks

Genetic Determinants of Diabetic Nephropathy in Type 2 Diabetes

Grzegorz Placha and Andrzej S. Krolewski

Major Risk Indicators for Diabetic Kidney Disease

Katherine R. Tuttle

B. Histopathology and Special Populations

The Structure of Human Diabetic Nephropathy

Michael Mauer and Behzad Najafian

Diabetic Kidney Disease in Transitional and Disadvantaged Populations

E. Jennifer Weil and Robert G. Nelson

C. Diagnosis and Treatment

Screening and Treatment of Early Diabetic Renal Disease in Type 1 and Type 2 Diabetes

Ellie Chuang and Mark E. Molitch

Treatment in Advanced Renal Disease in Type 1 and Type 2 Diabetes

Eberhard Ritz and Gunter Wolf

Diabetic and Renal Disease: ACE Inhibitors and/or Angiotensin Receptor Blockers: Does It Matter?

Carl Erik Mogensen and Niels Holmark Andersen

Management of Diabetic End-Stage Renal Disease With Dialysis

Ploumis S. Passadakis and Dimitrios G. Oreopoulos

D. Related Abnormalities

Diabetic Retinopathy and Nephropathy

Ronald Klein

Hypertension and Cardiovascular Disease

Adam Whaley-Connell, Kurt Sowers, and James R. Sowers

Endothelial Dysfunction and Diabetic Nephropathy

Coen D. A. Stehouwer, Maya S. P. Huijberts, Alfons J. H. M. Houben, and Nicolaas C. Schaper

Anemia and Diabetic Nephropathy

George Jerums, Richard MacIsaac, Sianna Panagiotopoulos, and Merlin Thomas

Index