Acute Myelogenous Leukemia Book

TABLE OF CONTENTS

I. Overview of AML: Francis Giles, MD Anderson

II. Molecular Foundations of AML Pathogenesis and Pathophysiology

A. Transcriptional Control of Myeloid Differentiation and Transformation: Alan Friedman, Johns Hopkins

B. Myelodysplasia-Related AML: Ghulam Mufti, King's College, London, England

C. Treatment-Related AML: Michelle LeBeau, University of Chicago

D. DNA Damage and Repair: David Steensma and Scott Kaufmann Mayo Clinic

E. Apoptosis: Ruben Mesa and Scott Kaufmann, Mayo Clinic

F. Drug Resistance Transporters: Douglas Ross, University of Maryland

III. Translating Biology into Clinical Application

A. Impact of Cytogenetics on Clinical Outcome: David Grimwade, Guy's Hospital, London, England

B. APL: A Classic Tale of Bench to Bedside: Martin Tallman, Northwestern

C. Molecular Therapeutics of AML: Selected Targeted Approaches

Overview: Edward Sausville, University of Maryland

FLT3: Mark Levis, Johns Hopkins

Farnesyltransferase: Jeffrey Lancet, Moffitt (University of South Florida)

Modulating Gene Expression as a Therapeutic Approach: Tamer Fandy,

Hetty Carraway, Steven Gore, Johns Hopkins

Growth Factor-Based Differentiation: William Matsui, Johns Hopkins

D. Stem Cell Transplantation: Richard Jones, Johns Hopkins

E. Vaccine Development: Ivan Borrello, Johns Hopkins

IV. Special Challenges

A. Pediatric AML: Robert Arceci, Johns Hopkins — pending

B. AML in the Elderly: Richard Stone, Dana Farber

C. Myeloproliferative Disorders: Jason Gottlib, Stanford

D. New Clinical Trials Designs: Elihu Estey, MD Anderson