Drug Delivery Systems Book

Preface v

Contributors ix

1 Drug Delivery Systems - An Overview Kewal K. Jain 1

2 The Role of the Adeno-Associated Virus Capsid in Gene Transfer Kim M. Van Vliet Veronique Blouin Nicole Brument Mavis Agbandje-McKenna Richard O. Snyder 51

3 Delivering Small Interfering RNA for Novel Therapeutics Patrick Y. Lu Martin C. Woodle 93

4 Catheters for Chronic Administration of Drugs into Brain Tissue Michael Guarnieri Benjamin S. Carson George I. Jallo 109

5 Transdermal Drug Delivery Systems: Skin Perturbation Devices Marc B. Brown Matthew J. Traynor Gary P. Martin Franklin K. Akomeah 119

6 Controlling the Release of Proteins/Peptides via the Pulmonary Route Sunday A. Shoyele 141

7 Engineering Protein Particles for Pulmonary Drug Delivery Sunday A. Shoyele 149

8 2B-Trans TM Technology: Targeted Drug Delivery Across the Blood-Brain Barrier Pieter J. Gaillard Albertus G. de Boer 161

9 Drug Delivery in Cancer Using Liposomes Crispin R. Dass 177

10 pH-Responsive Nanoparticles for Cancer Drug Delivery Youqing Shen Huadong Tang Maciej Radosz Edward Van Kirk William J. Murdoch 183

11 Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems Sandip B. Tiwari Ali R. Rajabi-Siahboomi 217

Index 245