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Chapter 1 The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery Qing Yan 1
Chapter 2 Applications of Microarrays and Biochips in Pharmacogenomics Gary Hardiman 21
Chapter 3 Confounding in Genetic Association Studies and Its Solutions Donglei Hu Elad Ziv 31
Chapter 4 Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung Erin R. Gardner Rui Gao William D. Figg 41
Chapter 5 Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy Tessa M. Bosch 63
Chapter 6 Pharmacogenomics of G Protein-Coupled Receptor Signaling: Insights from Health and Disease Miles D. Thompson David E. C. Cole Pedro A. Jose 77
Chapter 7 G Protein-Coupled Receptors Disrupted in Human Genetic Disease Miles D. Thompson Maire E. Percy W. McIntyre Burnham David E. C. Cole 109
Chapter 8 G Protein-Coupled Receptor Pharmacogenetics Miles D. Thompson Katherine A. Siminoivitch David E. C. Cole 139
Chapter 9 Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders Hamid Mostafavi Abdolmaleky Cassandra L. Smith Jin-Rong Zhou Sam Thiagalingam 187
Chapter 10 Pharmacogenomics in Alzheimer's Disease Ramon Cacabelos 213
Chapter 11 Pharmacogenetics of Asthma Gregory A. Hawkins Stephen P. Peters 359
Chapter 12 From SNPs to Functional Studies in Cardiovascular Pharmacogenomics Sharon Cresci 379
Chapter 13 Pharmacogenomics in Gastrointestinal Disorders Michael Camilleri Yuri A. Saito 395
Chapter 14 Pharmacogenomics in Rheumatoid Arthritis Prabha Ranganathan 413
Chapter 15 Cancer Pharmacogenetics Sharon Marsh 437
Chapter 16 Pharmacogenomics in thePreclinical Development of Vaccines: Evaluation of Efficacy and Systemic Toxicity in the Mouse Using Array Technology Karin J. Regnstrom 447
Chapter 17 Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines Lennart J. Nilsson Karin J. Regnstrom 469
Index 481
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William Roche
reviewed Pharmacogenomics in Drug Discovery and Development on January 07, 2009
Pharmacogenomics in Drug Discovery and Development
Full of humor and perhaps overfull of social criticism, Marks' book is an extremely thought provoking entryway into the softer side of science. I would advise anyone dipping their toes into the sciences to take a strenuous look at the ideas he raises, especially about scientific responsibility and the cultural ramifications of scientific study. To the animal rights activists out there, I just want to open this book to the human vs. animal rights page and SHMEAR it all over your faces. Not because I don't respect your cause, but because it's important. To remember. That people > animals, for the most part. IDK. All of his points made me slightly uncomfortable, which I appreciate, though sometimes his arguments felt a little holey.
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