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Opiate Receptors and Antagonists: From Bench to Clinic Book

Opiate Receptors and Antagonists: From Bench to Clinic
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  • Opiate Receptors and Antagonists: From Bench to Clinic
  • Written by author Reginald L. Dean
  • Published by Springer-Verlag New York, LLC, January 2009
  • The evolution in our understanding of Opioid receptors and their subtypes is intimately linked to the development of new pharmacological treatments for diseases and disorders as diverse as addiction, self-injurious behavior, pain, cancer, inflammation, ea
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Authors

Part I Opioid Receptors

1 Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance Lindsay H. Burns Todd W. Vanderah Hoau-Yan Wang 3

2 Upregulation of Opioid Receptors Ellen M. Unterwald Richard D. Howells 19

3 Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders Mark K. Greenwald Caren L. Steinmiller 45

4 Opioid Receptors Antagonist-Mediated Signaling in the Immune System Jonathan Moorman Zhi Qiang Yao Edward J. Bilsky Deling Yin 67

Part II Opioid Antagonists: Chemistry and Pharmacology

5 The Chemistry and Pharmacology of μ-Opioid Antagonists Jean M. Bidlack Jennifer L. Mathews 83

6 Medicinal Chemistry of Kappa Opioid Receptor Antagonists Cecile Beguin Bruce M. Cohen 99

7 The Chemistry and Pharmacology of Delta Opioid Antagonists Beatriz Fioravanti Todd W. Vanderah 119

8 Novel Opioid Antagonists with Mixed/Dual Selectivity Richard B. Rothman Subramaniam Ananthan Edward J. Bilsky 137

9 Experimental Utility and Clinical Potential of Irreversible Opioid Antagonists Ellen A. Walker Sandra D. Comer 153

10 Methylnaltrexone: A Peripherally Acting Opioid Antagonist Chun-Su Yuan Robert J. Israel 175

Part III Substance Abuse

11 Opioid Antagonist Effects in Animal Models Related to Opioid Abuse: Drug Discrimination and Drug Self-Administration S. Stevens Negus 201

12 Naltrexone for Initiation and Maintenance of Opiate Abstinence Kevin A. Sevarino Thomas R. Kosten 227

13 Ultra-Low-Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids Lindsay H. Burns Francesco Leri Mary C. Olmstead 247

14 Can a Combination Formulation Containing a Neutral Opiate Antagonist Decrease the Abuse ofμ-Agonist Opiates John Mendelson Mark Pletcher Gantt Galloway 263

15 Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine Brenda J. Gehrke Toni S. Shippenberg 273

16 Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence Bernard Le Foll Zuzana Justinova G. Tanda Marcello Solinas Peter Selby Steven R. Goldberg 299

17 Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions Andrea King Rachel Torello Suchitra Krishnan-Sarin Stephanie O'Malley 315

Part IV Alcohol and Ingestive Behaviors

18 Opioid Antagonists and Ethanol's Ability to Reinforce Intake of Alcoholic Beverages: Preclinical Studies Larry D. Reid 335

19 Clinical Use of Opioid Antagonists in the Treatment of Alcohol Dependence Raymond F. Anton 371

20 Preclinical Effects of Opioid Antagonists on Feeding and Appetite Richard J. Bodnar 387

21 CNS Opiate Systems and Eating Disorders Elliot D. Luby David Koval 407

Part V Behavioral Disorders

22 Potential Utility of Kappa Ligands in the Treatment of Mood Disorders William A. Carlezon Bruce M. Cohen 425

23 Opioid Antagonists in the Treatment of Pathological Gambling and Kleptomania Jon E. Grant 445

24 Efficacy of Opioid Antagonists in Attentuating Self-Injurious Behavior Curt A. Sandman 457

25 Pharmacotherapeutic Effects of Opioid Antagonists in Alcohol-Abusing Patients with Schizophrenia Ismene Petrakis 473

Part VI Medical Indications

26 Current Issues in the Use of Opioid Antagonists (Naltrexone for Opiate Abuse: A Re-Educational Tool as Well as an Effective Drug) Colin Brewer Emmanuel Streel 487

27 Emergency Room Use of Opioid Antagonists in Drug Intoxication and Overdose Simon F.J. Clarke Rob Torok Paul I. Dargan Alison L. Jones 511

28 Kappa-Opioid Antagonists as Pruritogenic Agents Alan Cowan Saadet Inan 541

29 Clinical Effect of Opioid Antagonists on Clinical Pruritus Nora V. Bergasa 551

30 Effects of Opioid Antagonists on L-DOPA-Induced Dyskinesia in Parkinson's Disease Susan H. Fox Tom H. Johnston Jonathan M. Brotchie 569

31 Endocrine Effects of Opioid Antagonists Jack H. Mendelson Nancy K. Mello 581

32 Opioid Antagonists in Traumatic Shock: Animal and Human Studies Liangming Liu 605

33 The Efficacy of Opioid Antagonists Against Heatstroke-Induced Ischemia and Injury in Rats Mao-Tsun Lin Ching-Ping Chang Sheng-Hsien Chen 625

34 A Review of the Opioid System in Cancer Patients and Preliminary Results of Opioid Antagonists in the Treatment of Human Neoplasms Paolo Lissoni 641

35 Nonclinical Pharmacology of VIVITROL®: A Monthly Injectable Naltrexone for the Treatment of Alcohol Dependence Reginald L. Dean, III 655

36 The Development of Sustained-Release Naltrexone and Clinical Use in Treating Opiate Dependence Gary K. Hulse Sandra D. Comer Maria A. Sullivan 675

37 The Development of ProNeura Technology for the Treatment of Addictions Lauren C. Costantini 689

38 Development of Opioid Transdermal Delivery Systems Kalpana S. Paudel Stan L. Banks Paul K. Kiptoo Dana C. Hammell R. Reddy Pinninti Caroline Strasinger Audra L. Stinchcomb 709

39 Intranasal Naloxone for Treatment of Opioid Overdose Anne-Maree Kelly Debra Kerr Paul Dietze 729

Index 741


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