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Dedication v
Series Editor's Introduction vii
Foreword xi
Preface xiii
Contributors ixx
Adipose Tissue: Structure and Function
The Adipose Organ Saverio Cinti 3
Metabolism of White Adipose Tissue Michel Beylot 21
Leptin Malaka B. Jackson Rexford S. Ahima 35
Adiponectin Aimin Xu Yu Wang Karen S. L. Lam 47
Adipokines as Regulators of Immunity and Inflammation
Vasoactive Factors and Inflammatory Mediators Produced in Adipose Tissue Gema Fruhbeck 63
Regulation of the Immune Response by Leptin Victor Sanchez-Margalet Patricia Fernandez-Riejos Carmen Gonzalez-Yanes Souad Najib Consuelo Martin-Romero Jose Santos-Alvarez 19
Leptin in Autoimmune Diseases Giuseppe Matarese 91
Leptin and Gastrointestinal Inflammation Arvind Batra Britta Siegmund 101
Adiponectin and Inflammation Yuji Matsuzawa 111
Interactions Between Adipocytes and Immune Cells
Macrophages, Adipocytes, and Obesity Anthony W. Ferrante, Jr. 121
Interactions of Adipose and Lymphoid Tissues Caroline M. Pond 133
Adipose Tissue and Mast Cells: Adipokines as Yin-Yang Modulators of Inflammation George N. Chaldakov Anton B. Tonchev Nese Tuncel Pepa Atanassova Luigi Aloe 151
Bone Marrow Adipose Tissue Patrick Laharrague Louis Casteilla 159
Weight Gain and Weight Loss
The Epidemiology of Obesity Carol A. Braunschweig 183
Environmental Aspects of Obesity Lisa Diewald Meredith S. Dolan Myles S. Faith 197
Developmental Perspectives on the Origins of Obesity Christopher W. Kuzawa Peter D. Gluckman Mark A. Hanson 207
Genetics of Obesity: Five Fundamental Problems With the Famine Hypothesis John R. Speakman 221
Inherited and Acquired Lipodystrophies: Disorders of Adipose Tissue Development, Differentiation, and Death Vinaya Simha Anil K. Agarwal 237
Mechanisms of Cachexia Robert H. Mak Wai W. Cheung 255
Effect of Weight Loss on Disease Sergio Jose Bardaro Dennis Hong Lee Swanstrom 265
Adipose Tissue and Disease
Adipose Tissue and Insulin Resistance Stephen E. Borst 281
Adipokines in Non-Alcoholic Fatty Liver Disease Ancha Baranova Zobair M. Younossi 291
Adiposity and Cancer Eugenia E. Calle 307
Obesity and the Heart Alison M. Morris Paul Poirier Robert H. Eckel 327
Obesity and Asthma Elisabeth Luder 341
Adiposity and Kidney Disease Srinivasan Beddhu Bonnie Ching-Ha Kwan 351
Obesity and Joint Disease Andrew J. Teichtahl Anita E. Wluka Flavia M. Cicuttini 359
Appendices 373
Index 385
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