Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy Book

In Memoriam     v
Foreword     vii
Preface     ix
Biography     xiii
Contributors     xix
Transforming Growth Factor-[beta] in Developing and Advanced Cancers
Transforming Growth Factor-[beta] Signaling in Pancreas Development and Pancreatic Disease   Sushil G. Rane   Huei-Min Lin   Ji-Hyeon Lee     3
Role of Transforming Growth Factor-[beta] in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma   Stephen M. Weber   Shi-Long Lu   Sophia Bernstein   Xiao-Jing Wang     21
TGF-[beta], Smads and Cervical Cancer   Devarajan Karunagaran   Goodwin Jinesh     33
TGF-[beta] Signaling and Biglycan in Pancreatic Cancer   Hendrik Ungefroren     51
TGF-[beta] Signaling in Endometrial Cancer   Dagmara Piestrzeniewicz-Ulanska   David H. McGuinness   Grant R. Yeaman     63
TGF-[beta] Ligands, TGF-[beta] Receptors, and Lung Cancer   Guiying Y. Wang   Xiaochua H. Hu   Rongmei M. Zhang   Lindsey Leach   Zewei W. Luo     79
Role of TGF-[beta] in Osteolytic Bone Metastases   Laurent Bartholin   Theresa Guise     95
Hormonal Regulation of Transforming GrowthFactor-[beta] in Breast Cancer   Miriam Buck   Cornelius Knabbe     125
TGF-[beta] and Progression of Esophageal Cancer   Minoru Fukuchi   Hiroyuki Kato   Hiroyuki Kuwano     133
TGF-[beta] and HER2/ErbB2 and Breast Cancer Progression   Natasa Todorovic-Rakovic     141
TGF-[beta] Dependent T-Cell Regulation in Colitis and Colon Cancer   Christoph Becker   Markus F. Neurath     153
Role of Transforming Growth Factor-[beta] in the Kidney-Physiology and Pathology   Elena Gagliardini   Ariela Benigni     167
Perturbations of TGF-[beta] Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis   Lawrence A. Wolfraim   John J. Letterio     181
Transforming Growth Factor-[beta] in Brain Functions and Dysfunctions   Denis Vivien   Karim Benchenane   Carine Ali     203
Inhibition of TGF-[beta] Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment   Hiroshi Yasui   Teru Hideshima   Kenneth C. Anderson     219
Key Roles of TGF-[beta] and Smad3 in Prostate Cancer   Kyung Song   David Danielpour     229
Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-[beta] Type I Receptor   Francis Ruscetti   Salem Akel   Maria Birchenall-Roberts   Zhouhong Cao   Anita B. Roberts     247
Transforming Growth Factor-[beta] in Cancer Treatment and Therapy
High-Throughput Screening of Protein Interaction Networks in the TGF[beta] Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression   Miriam Barrios-Rodiles   Alicia Viloria-Petit   Kevin R. Brown   Igor Jurisica   Jeffrey L. Wrana     265
Tumor Suppressor and Pro-progression Roles for TGF-[beta] in Breast Cancer   Ethan A. Kohn   Binwu Tang     285
Tumor Suppressors p53 and TGF[beta] Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker   Deepti S. Wilkinson   Michelle Craig Barton     309
TGF[beta]: Roles in DNA Damage Responses   Kumari L. Andarawewa   Julia Kirshner   Joni D. Mott   Mary Helen Barcellos-Hoff     321
The Rationale for and Effects of Targeting TGF-[beta] for Glioma Therapy   Anita B. Hjelmeland   Jeremy N. Rich     335
Tumor Suppressor Functions of TGF[beta]1 in T Cells   Ramireddy Bommireddy   Thomas Doetschman     353
Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-[beta] Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization   Shizuya Saika     367
Role of TGF-[beta] in Tumor Protection and Antitumor Immunity   Catherine M. Bollard   Cliona M. Rooney     383
Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1   Karen O. Yee   Jack Lawler     401
Cancer-Associated Fibroblasts and the Role of TGF-[beta]   Patrick Micke   Aristidis Moustakas   Mitsuhiro Ohshima   Kai Kappert     417
Adoptive Transfer of Tumor Reactive TGF-[beta] Insensitive CD8[superscript +] T-cells for Cancer Therapy   Chung Lee   Ali Shah   Victoria C. Liu   Irwin I. Park   Larry Y. Wong   Xuemei Huang   Lijun Huang   Vivian W. Zhou   Terry Medler   Shilajit D. Kundu   Qiang Zhang   Norm D. Smith     443
DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-[beta] Signaling in Breast Cancer   Sudhakar Ammanamanchi   Michael G. Brattain     463
Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-[beta], Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities   David R. Rowley     475
TGF-[beta] Signaling and Vascular Morphogenesis   Evangelia Pardali   Zhen Liu   Marion Scharpfenecker   Peter ten Dijke     507
Aberrant Transforming Growth Factor-[beta] Signaling in Human Pancreatic Cancer: Translational Implications   Murray Korc     523
TGF-[beta] and Stromal Influences Over Local Tumor Invasion   Sylviane Dennler   Alain Mauviel   Franck Verrecchia     537
TGF-[beta] at the Crossroads Between Inflammation, Suppression and Cancer   Nancy L. McCartney-Francis   Sharon M. Wahl     553
Development of Inhibitors of Transforming Growth Factor-[beta] Signaling for Therapy
Transforming Growth Factor-[beta] (TGF-[beta]) Signaling Inhibitors in Cancer Therapy   Pran K. Datta   Jason R. Mann     573
Targeting TGF-[beta] as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy   Marjan Boerma   Junru Wang   Michael J. Corbley   Martin Hauer-Jensen     589
Targeting Transforming Growth Factor-[beta] in Metastasis: In Vitro and In Vivo Mechanisms   Michael Reiss     609
Targeted Downregulation of TGF-[beta]2 with AP 12009 in Tumor Therapy   Karl-Hermann Schlingensiepen   Piotr Jachimczak   Birgit Fischer-Blass   Dagmar Fischer   Heike Specht   Susanne Schmaus    Reimar Schlingensiepen     635
Modulating TGF-[beta] Receptor Signaling: A Novel Approach of Cancer Therapy   Ulrike Naumann   Michael Weller     653
Engineering TGF-[beta] Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-[beta] Action   Gregory De Crescenzo   Heman Chao   John Zwaagstra   Yves Durocher   Maureen D. O'Connor-McCourt     671
The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology   Leona E. Ling   Juswinder Singh   Claudio E. Chuaqui   P. Ann Boriack-Sjodin   Michael J. Corbley   Doreen J. Lepage   Erika L. Silverio   Lihong Sun   James L. Papadatos   Feng Shan   Timothy Pontz   H.-Kam Cheung   Xiamei Zhang   Robert M. Arduini   Jonathan N. Mead   Miki N. Newman   Scott Bowes   Serene Josiah   Wen-Cherng Lee     685
Soluble Type II Transforming Growth Factor-[beta] Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity   Eiji Suzuki   Steven M. Albelda     697
Reversal of EMT by Small-Molecule Inhibitors of TGF-[beta] Type I and II Receptors: Implications for Carcinoma Treatment   Markus D. Lacher   W. Michael Korn   Rosemary J. Akhurst     707
Soluble TGF-[beta] Type III Receptor Suppresses Malignant Progression of Human Cancer Cells   Abhik Bandyopadhyay   LuZhe Sun     723
Targeting Smad-Dependent TGF-[beta] Signaling with Peptide Aptamers   F. Michael Hoffmann   Qiqi Cui   S. Kyun Lim   Bryan M. Zhao     737
Rationale for Anti-TGF-[beta] Antibody Therapy in Oncology   Frank J. Hsu   Beverly A. Teicher   John M. McPherson     757
Index     775