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Part I Cannabinoid Receptor Ligands and Structure-Activity Relationships
1 Structure-Activity Relationships of Classical Canabinoids Raj K. Razdan 3
2 Endocannabinoids and Their Synthetic Analogs V. Kiran Vemuri Alexandros Makriyannis 21
3 Cannabimimetic Indoles, Pyrroles, and Indenes: Structure-Activity Relationships and Receptor Interactions John W. Huffman 49
4 Structure-Activity Relationships and Conformational Freedom of CB1 Receptor Antagonists and Inverse Agonists Yanan Zhang Herbert H. Seltzman Marcus Brackeen Brian F. Thomas 95
Part II Cannabinoid Receptor Biology
5 Cannabinoid Receptor Genetics and Evolution Maurice R. Elphick Michaela Egertova 123
Part III Cannabinoid Receptor Molecular Pharmacology
6 Cannabinoid Receptor Signal Transduction Pathways Emma Scotter Scott Graham Michelle Glass 153
7 Cannabinoid Agonist and Inverse Agonist Regulation of G Protein Coupling Allyn C. Howlett Lea W. Padgett Joong-Youn Shim 173
8 Molecular Biology of Cannabinoid Receptors: Mutational Analyses of the CB Receptors Mary E. Abood 203
9 Models of Cannabinoid Inverse Agonism, Neutral Antagonism, and Agonism: Tools for Rational Drug Design Dow P. Hurst Patricia H. Reggio 235
Part II The Endocannabinoid System
10 Endocannabinoids as Modulators of Synaptic Signaling Sachin Patel Cecilia J. Hillard 281
11 New Insights into the Endocannabinoid System by Using Cannabinoid Receptor Knockout Mice Meliha Karsak Itai Bab Andreas Zimmer 309
Part V Cannabinoid Receptor Pharmacology
12 Preclinical Pharmacological and Brain Bioassay Systems for CB1 Cannabinoid Receptors Jenny L. Wiley Billy R. Martin 329
13 Therapeutic Applications for Agents that Act at CB1and CB2 Receptors Roger G. Pertwee Adele Thomas 361
Index 393
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