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Preface v
Contributors xi
Contents of Volume 1 xv
Kinases and Phosphatases
Significance of Protein Kinase A in Cancer Maria V. Nesterova Yoon S. Cho-Chung 3
Protein Kinase C and Apoptosis Mary E. Reyland 31
The Role of Phosphoinositide 3-Kinase-Akt Signaling in Virus Infection Samantha Cooray 57
Cyclin-Dependent Kinase 5: A Target for Neuroprotection? Frank Gillardon 81
Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance James A. McCubrey Fred E. Bertrand Linda S. Steelman Fumin Chang David M. Terrian Richard A. Franklin 101
MAPK Signaling in Human Diseases Philippe P. Roux John Blenis 135
Serine/Threonine Protein Phosphatases in Apoptosis Gro Gausdal Camilla Krakstad Lars Herfindal Stein Ove Doskeland 151
Urokinase/Urokinase Receptor-Mediated Signaling in Cancer Sreerama Shetty Steven Idell 167
Molecular Basis of Cell Death
Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion Zheqing Cai Gregg L. Semenza 181
Cyclooxygenase-2 Gene Expression: Transcriptional and Posttransciptional Conrols in Intestinal Tumorigenesis Shrikant Anant Sripathi M. Sureban 197
Death Receptors: Mechanisms, Biology, and Therapeutic Potential Sharmila Shankar Rakesh Srivastava 219
DNA Damage-Dependent Apoptosis Tomasz Skorski 263
The Role of Proteasome in Apoptosis Peter Low 273
Apoptosis Induction in T Lymphocytes by HIV Maria Saveria Gilardini Montani 295
Inhibitors of Apoptosis Proteins and Caspases Jai Y. Yu John Silke Paul G. Ekert 313
Intracellular Pathways Involved in DNA Damage and Repair to Neuronal Apoptosis Maurizio Memo 335
The Biology of Caspases Tasman James Daish Sharad Kumar 347
Apoptosis and Human Diseases: Molecular Mechanisms: Oxidative Stress in the Pathogenesis of Diabetic Neuropathy Mahdieh Sadidi Ann Marie Sastry Christian M. Lastoskie Andrea A. Vincent Kelli A. Sullivan Eva L. Feldman 365
Index 395
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