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Preface | ||
Contributors | ||
Pt. I | Basic Principles | |
1 | Thrombosis in Acute Coronary Syndromes and Coronary Interventions | 3 |
2 | Platelet Adhesion | 23 |
3 | Glycoprotein IIb/IIIa in Platelet Aggregation and Acute Arterial Thrombosis | 39 |
4 | Glycoprotein IIb/IIIa Antagonists: Development of Abciximab and Pharmacology of Abciximab, Tirofiban, and Eptifibatide | 73 |
Pt. II | Glycoprotein IIb/IIIa Blockade During Coronary Intervention | |
5 | Abeiximab During Percutaneous Coronary Intervention: EPIC, EPILOG, and EPISTENT Trials | 105 |
6 | Eptifibatide in Coronary Intervention: The IMPACT and ESPRIT Trials | 125 |
7 | Tirofiban in Interventional Cardiology: The RESTORE and TARGET Trials | 147 |
8 | Overview of the Glycoprotein IIb/IIIa Interventional Trials | 167 |
Pt. III | Glycoprotein IIb/IIIa Blockade for Acute Ischemic Syndromes | |
9 | The Use of Abciximab in Therapy-Resistant Unstable Angina: Clinical and Angiographic Results of the CAPTURE Pilot Trial and the CAPTURE Study | 203 |
10 | Unstable Angina Trials: PARAGON, PURSUIT, PRISM, PRISM-PLUS, and GUSTO-IV | 233 |
11 | Platelet Glycoprotein IIb/IIIa Inhibitors and an Invasive Strategy | 263 |
12 | Glycoprotein IIb/IIIa Receptor Blockade in Myocardial Infarction: Adjunctive Therapy to Percutaneous Coronary Interventions | 275 |
13 | Glycoprotein IIb/IIIa Receptor Blockade in Acute Myocardial Infarction: Adjunctive Therapy to Fibrinolysis | 289 |
Pt. IV | Practical Issues and Future Applications | |
14 | Economics of Glycoprotein IIb/IIIa Inhibition | 305 |
15 | Platelet Monitoring and Interaction of Glycoprotein IIb/IIIa Antagonists with Other Antiplatelet Agents | 321 |
16 | Platelet Glycoprotein IIb/IIa Antagonists: Their Interaction with Low-Molecular-Weight Heparins and Direct Thrombin Inhibitors | 341 |
17 | Oral Agents | 365 |
18 | Platelet Glycoprotein IIb/IIIa Inhibitors: Effects Beyond the Platelet | 383 |
19 | Cerebrovascular Interventions | 397 |
20 | Cerebrovascular Aspects of Glycoprotein IIb/IIIa Receptor Inhibitors | 409 |
21 | Evolution of Drug Development in Evidence-Based Medicine: Summary and the Future | 425 |
Index | 459 |
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