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Preface | ||
Contributors | ||
Pt. I | Historical Perspectives | |
1 | Dietary Fatty Acids. COX-2 Blockade, and Carcinogenesis | 3 |
2 | Historical Aspects of COX-2: Cloning and Characterization of the cDNA. Protein and Gene | 13 |
Pt. II | Epidemiology of NSAIDs and Cancer | |
3 | Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer | 35 |
4 | Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer | 57 |
Pt. III | Animal Models of Carcinogenesis | |
5 | Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention | 71 |
6 | Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals | 85 |
7 | The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer | 99 |
8 | Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis | 117 |
9 | Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs | 147 |
Pt. IV | Molecular Biology of COX-2 | |
10 | Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis | 159 |
11 | Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2 | 171 |
12 | Cyclooxygenase-2 and Cancer | 185 |
13 | Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells | 205 |
14 | Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention | 225 |
15 | Carcinogenesis Involving Cyclooxygenase and Lipoxygenase | 245 |
Pt. V | Clinical Applications | |
16 | The Development of Drugs that Target Cyclooxygenase-2 | 259 |
17 | Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade | 279 |
18 | Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse | 301 |
19 | Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy | 313 |
20 | Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact | 341 |
Index | 367 |
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