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Cox-2 Blockade in Cancer PreventionTherapy Book

Cox-2 Blockade in Cancer PreventionTherapy
Cox-2 Blockade in Cancer PreventionTherapy, , Cox-2 Blockade in Cancer PreventionTherapy has a rating of 4 stars
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  • Cox-2 Blockade in Cancer PreventionTherapy
  • Written by author Randall E. Harris
  • Published by Springer-Verlag New York, LLC, September 2002
  • Forty-one of the leading American experts contribute 20 chapters discussing the evidence and new opportunities for the use of cyclooxygenase-2 (COX-2) blockage in the prevention and treatment of cancer. Coverage includes an historical overview of the scie
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Preface
Contributors
Pt. IHistorical Perspectives
1Dietary Fatty Acids. COX-2 Blockade, and Carcinogenesis3
2Historical Aspects of COX-2: Cloning and Characterization of the cDNA. Protein and Gene13
Pt. IIEpidemiology of NSAIDs and Cancer
3Epidemiology of Nonsteroidal Anti-Inflammatory Drugs and Colorectal Cancer35
4Epidemiology of Breast Cancer and Nonsteroidal Anti-Inflammatory Drugs: Extension of the Dietary Fat Hypothesis of Breast Cancer57
Pt. IIIAnimal Models of Carcinogenesis
5Role of Synthetic and Naturally Occurring Cyclooxygenase Inhibitors in Colon Cancer Prevention71
6Chemoprevention of Breast Cancer by Nonsteroidal Anti-Inflammatory Drugs and Selective COX-2 Blockade in Animals85
7The Role of Cyclooxygenase-2 in the Prevention and Therapy of Lung Cancer99
8Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc-Driven Intestinal Tumorigenesis117
9Cyclooxygenase-1 and Cyclooxygenase-2 Knockout Mice Provide Insights into Beneficial and Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs147
Pt. IVMolecular Biology of COX-2
10Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis159
11Regulation of Expression and Potential Carcinogenic Role of Cyclooxygenase-2171
12Cyclooxygenase-2 and Cancer185
13Interactions of Cyclooxygenase and Aromatase Pathways in Normal and Malignant Breast Cells205
14Association of COX-2 and PPARs in Carcinogenesis and Chemoprevention225
15Carcinogenesis Involving Cyclooxygenase and Lipoxygenase245
Pt. VClinical Applications
16The Development of Drugs that Target Cyclooxygenase-2259
17Chemoprevention of Cancer by NSAIDs and Selective COX-2 Blockade279
18Potential for Inhibitors of Cyclooxygenase-2 to Enhance Tumor Radioresponse301
19Potential Role of NSAIDs and COX-2 Blockade in Cancer Therapy313
20Cyclooxygenase-2 Blockade in Cancer Prevention and Therapy: Widening the Scope of Impact341
Index367


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