Drug Discovery and Design: Medical Aspects, Vol. 55 Book

	Preface	v
Part I	Synthesis and Properties of Bioactive Compounds
	Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity	3
	Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro	13
	Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro	20
	Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected [alpha]-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes with Metal Ions	25
	L-Asparaginase: Structure, Properties and Anti-Tumor Activity	33
	Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma	41
	Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues	53
	Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery	64
	Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate Semialdehydes	76
	Development of New Methods for Fluorometric Assays of Enzymes	83
	Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam	97
	In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus	103
	Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[subscript 1-11]	116
Part II	Role of Membranes in Drug Activity
	The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer Membranes	125
	Stealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma	131
	Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, [beta]-Ala-Tyr from Larvae of the Gray Flesh Fly	142
	Effects of NSAIDs in Membrane Bilayers	150
Part III	Conformational Analysis of Bioactive Compounds
	The Structure of Endotoxin-Neutralizing Peptides Bound to LPS	161
	Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic Resonance	167
	Structure Elucidation and Conformational Properties of Irbesartan	174
	[superscript 1]H and [superscript 13]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis	180
	Conformational Analysis of Biomolecules in Solution: NMR--3D Structures--Biological Implications	188
	Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution	205
	Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues	217
Part IV	Molecular Targets and Drug Design
	Molecular Aspects of Human Abdominal Aortic Aneurysm: Differential Expression of Genes Coding for Extracellular Matrix Proteoglycans	229
	Advances in Botulinum Neurotoxin Inhibitors Based on the SNARE Motif	236
	Effect of Linear and Cyclic Peptide Analogues of Myelin Basic Protein Epitope MBP[subscript 72-85] on Human T-cell Activation	241
	Use of Synthetic Peptides for the Identification of the Biologically Active Domains of the Growth Factor HARP	251
	Unusual Interactions between MHC, Peptide and the T cell Receptor	258
	Effects of Angiotensin II, III and IV on Memory Retention of Rats: Interaction with Adenosine A[subscript 1] Receptor Related Ligands	267
	Molecular Targets and Compounds for Anti-HIV Therapy	272
	Proteomics in Drug Discovery: Potential and Limitations	279
	Evaluation of Tumor Capabilities for Recurrence in Patients with Larynx and Pharynx Malignancies on the Basis of DNA Criterion	294
	Significance of G-protein-coupled Receptor Polymorphisms: The Case of [alpha subscript 2]-adrenergic Receptor	299
	Computer Graphics Applications on Molecular Biology and Drug Design	305
	Investigation of Novel DNA Gyrase Inhibitors Using the High Resolution NMR Spectroscopy	312
	Author Index	323