Cooley's Anemia: Eighth Symposium Book

	Thalassemia : the continued challenge	1
	Keynote address : the challenge of Thalassemia for the developing countries	11
	Changing patterns of Thalassemia worldwide	18
	[alpha]-Thalassemia : Hb H disease and Hb bans hydrops fetalis	25
	Hemoglobin E-[beta]-Thalassemia : progress report from the international study group
	Survival and complications in Thalassemia
	Role of intergenic human [gamma]-[delta]-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells	48
	Isolation and characterization of hematopoietic transcription factor complexes by in Vivo biotinylation tagging and mass spectrometry
	Germline epimutation : a basis for epigenetic disease in humans	68
	Progress toward the genetic treatment of the [beta]-Thalassemias	78
	Understanding [alpha]-globin gene regulation : aiming to improve the management of Thalassemia
	Role of alpha hemoglobin-stabilizing protein in normal erythropoiesis and [beta]-Thalassemia	103
	Role of iron in inducing oxidative stress in Thalassemia : can it be prevented by inhibition of absorption and by autioxidants?	118
	Objectives and mechanism of iron chelation therapy	124
	Ferritin as an iron concentrator and chelator target	136
	The design of orally active iron chelators	141
	Recent insights into interactions of deferoxamine with cellular and plasma iron pools : implications for clinical use	155
	Deferiprone : new insight	169
	Combined therapy with deferroxamine and deferiprone	175
	Evaluation of ICL670, a once-daily oral iron chelator in a phase III clinical trial of [beta]-Thalassemia patients with transfusional iron overload	183
	Unrelated bone marrow transplantation for [beta]-Thalassemia patients : the experience of the Italian bone marrow transplant group
	Bone marrow transplantation in adults with Thalassemia : treatment and long-term follow-up	196
	Sibling donor cord blood transplantation for Thalassemia major : experience of the sibling donor cord blood program
	Stem cell transplantation with S-59 photochemically treated T-cell add-backs to establish allochimerism in Murine Thalassemia	214
	Preimplantation genetics : improving access to stem cell therapy	223
	Pharmacological induction of fetal hemoglobin : why haven't we been more successful in Thalassemia?	228
	Successful correction of the human Cooley's anemia [beta]-Thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator	238
	Single and combination plug therapy for fetal hemoglobin augmentation in hemoglobin E-[beta][superscript 0]-Thalassemia : considerations for treatment
	Induction of fetal globin in [beta]-Thalassemia : cellular obstacles and molecular progress	257
	Caring for adults with Thalassemia in a pediatric world	266
	Quality of life in Thalassemia	273
	Thalassemia and learning : neurocognitive function in children	283
	Treatment of hepatitis C virus infection in Thalassemia	290
	Fertility and pregnancy in Thalassemia major	300
	A phase I/II clinical trial of [beta]-globin gene therapy for [beta]-Thalassemia	308
	Coagulation and splenectomy : an overview	317
	Transfusion safety : where are we today?	325
	Pulmonary hypertension in [beta]-Thalassemia	342
	Monitoring long-term efficacy of iron chelation treatment with biomagnetic liver susceptometry	350
	Methods for noninvasive measurement of tissue iron in Cooley's anemia
	T2* magnetic resonance and myocardial iron in Thalassemia	373
	Measurement and mapping of liver iron concentrations using magnetic resonance imaging	379
	Physiology and pathophysiology of iron cardiomyopathy in Thalassemia	386
	Eighth Cooley's anemia symposium : summation and perspective	396
	Rescued mice with Hb E transgene-developed red cell changes similar to human [beta]-Thalassemia/HbE disease	407
	Exploring the role of hepcidin, an antimicrobial and iron regulator peptide, in increased iron absorption in [beta]-Thalassemia
	Murine and math models for the level of stable mixed chimerism to cure [beta]-Thalassemia by nonmyeloablative bone marrow transplantation	423
	Non-transferrin-bound iron during blood transfusion cycles in [beta]-Thalassemia major	429
	Genetic analysis of candidate modifier polymorphisms in HbE-[beta][superscript 0]-Thalassemia patients	433
	Measuring chromosome breaks in patients with Thalassemia	439
	Longitudinal study of survival and causes of death in patients with Thalassemia major in Greece	445
	Osteoporosis in [beta]-Thalassemia : clinical and genetic aspects	451
	Quality of life in patients with Thalassemia intermedia compared to Thalassemia major	457
	Low bone mineral density in adolescents with [beta]-Thalassemia	462
	Does heterozygous [beta]-Thalassemia confer a protection against coronary artery disease?	467
	Therapeutic approaches to pulmonary hypertension in hemoglobinopathies : efficacy and safety of sildenafil in the treatment of severe pulmonary hypertension in patients with hemoglobinopathy	471
	Utility of Holter electrocardiogram in iron-overloaded hemoglobinopathies	476
	Hemolysis-associated pulmonary hypertension in Thalassemia	481
	A simple model to assess and improve adherence to iron chelation therapy with deferoxamine in patients with Thalassemia
	Preclinical and clinical development of deferitrin, a novel, orally available iron chelator	492
	Allosensitization in patients receiving multiple blood transfusions	495
	Outcomes of preimplantation genetic diagnosis therapy in treatment of [beta]-Thalassemia : a retrospective analysis	500