Biomarkers of Environmentally Associated Disease: Technologies,Concepts,and Perspectives Book

Ch. 1	Overview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health	3
Ch. 2	Ethical and Legal Considerations in Biological Markers Research	17
Ch. 3	Scientific and Policy Issues Affecting the Future of Environmental Health Sciences	27
Ch. 4	Ecogenetics: Genetic Susceptibility to Environmental Adversity	39
Ch. 5	Toxicogenomics and Pharmacogenomics: Basic Principles, Potential Applications, and Issues	55
Ch. 6	Individual Susceptibility to Exposures: A Role for Genetic Variation in DNA Repair Genes	63
Ch. 7	Studies of DNA Repair and Human Cancer: An Update	83
Ch. 8	DNA Adducts as Biomarkers of DNA Damage in Lung Cancer	109
Ch. 9	Tamoxifen-DNA Adducts: Biomarkers for Drug-Induced Endometrial Cancer	127
Ch. 10	Polycyclic Aromatic Hydrocarbon DNA Adducts and Human Cancer	139
Ch. 11	Quantitative PCR: A Sensitive Biomarker of Gene-Specific DNA Damage and Repair	159
Ch. 12	Fidelity of DNA Synthesis as a Molecular Biomarker	171
Ch. 13	Mutational Specificity of Environmental Carcinogens	183
Ch. 14	Learning-Induced Modulation of Neural Cell Adhesion Molecule Polysialylation State as a Biomarker of Prior Inorganic Lead Exposure during the Early Postnatal Period	211
Ch. 15	Molecular Biomarkers for Mercury	225
Ch. 16	Validity of Mercury Exposure Biomarkers	235
Ch. 17	Urinary Arsenic Species in Relation to Drinking Water, Toenail Arsenic Concentrations and Genetic Polymorphisms in GSTM1 in New Hampshire	249
Ch. 18	Molecular Responses of Mammalian Cells to Nickel and Chromate Exposure	261
Ch. 19	Chromium: Exposure, Toxicity, and Biomonitoring Approaches	267
Ch. 20	Using Plankton Food Web Variables as Indicators for the Accumulation of Toxic Metals in Fish	287
Ch. 21	Validation of Exposure and Risk Biomarkers: Aflatoxin as a Case Study	307
Ch. 22	Biomarkers of Early Effect in the Study of Cancer Risk	319
Ch. 23	Proteomics in Toxicology: An Experience with Gentamicin	335
Ch. 24	Xenopus laevis Genomic Biomarkers for Environmental Toxicology Studies	339
Ch. 25	Molecular Biomarkers Targeting Signal Transduction Systems: The AH Receptor Pathway	355
Ch. 26	Measuring Oxidative Damage Caused by Environmental Stressors: Potential for Reversal and Abatement	365
Ch. 27	Biomarkers of Male Reproductive Health	387
Ch. 28	Peripheral Benzodiazepine Receptors: Molecular Biomarkers of Neurotoxicity	411
Ch. 29	Biomarkers of Organ Injury from Chemical Exposure: Concurrent Inflammation as a Determinant of Susceptibility	431
Ch. 30	Modulation of GAP Junctional Communication by "Epigenetic" Toxicants: A Shared Mechanism in Teratogenesis, Carcinogenesis, Atherogenesis, Immunomodulation, Reproductive and Neurotoxicities	445
Ch. 31	Exposure to POPs and Other Congeners	455
Ch. 32	Polybrominated Diphenyl Ethers: Route, Dose, and Kinetics of Exposure to Humans	471
Ch. 33	Bioanalytical Approaches for the Detection of Dioxin and Related Halogenated Aromatic Hydrocarbons	483
Ch. 34	Application of Biomarkers to Population Studies on Food Chain Contaminants in Nunavik (Arctic Quebec, Canada)	495
Ch. 35	University-Community Partnership for the Study of Environmental Contamination at Akwesasne	507
Ch. 36	Electronic Biosensing	527
Ch. 37	Two-Photon Fluorescence Microscopy: A Review of Recent Advances in Deep-Tissue Imaging	549
	Index	565