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Dermatotoxicology Methods: The Laboratory Worker's Ready Reference Book

Dermatotoxicology Methods: The Laboratory Worker's Ready Reference
Dermatotoxicology Methods: The Laboratory Worker's Ready Reference, This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune syst, Dermatotoxicology Methods: The Laboratory Worker's Ready Reference has a rating of 4 stars
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Dermatotoxicology Methods: The Laboratory Worker's Ready Reference, This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune syst, Dermatotoxicology Methods: The Laboratory Worker's Ready Reference
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  • Dermatotoxicology Methods: The Laboratory Worker's Ready Reference
  • Written by author Francis N. Marzulli
  • Published by Informa Healthcare, June 1998
  • This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune syst
  • This work presents and evaluates methods employed to identify the potential of certain types of chemicals to adversely affect the skin. A variety of test methods are included such as tests for skin penetration, metabolism, irritation, the skin immune syst
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Preface
Preface to Dermatotoxicology, Fifth Edition
Ch. 1Structure-Activity Relationships in Percutaneous Absorption1
Ch. 2Methods for in Vitro Percutaneous Absorption7
Ch. 3Percutaneous Absorption in Humans15
Ch. 4Percutaneous Absorption of Hazardous Substances from Soil and Water29
Ch. 5Isolated Perfused Porcine Skin Flap41
Ch. 6Methods in Physiologically Based Pharmacokinetic Modeling51
Ch. 7Methods for In Vitro Skin Metabolism Studies69
Ch. 8Developing a Toxicology Evaluation Plan for Transdermal Delivery Systems75
Ch. 9Animal, Human, and In Vitro Test Methods for Predicting Skin Irritation89
Ch. 10Structure-Activity Relationships in Contact Sensitization: Classification and Ranking of Allergens115
Ch. 11Test Methods for Allergic Contact Dermatitis in Animals121
Ch. 12The Local Lymph Node Assay145
Ch. 13Test Methods for Allergic Contact Dermatitis in Humans153
Ch. 14Contact Urticaria Syndrome161
Ch. 15Diagnostic Tests in Dermatotoxicology177
Ch. 16Use of Cytokines in Dermatotoxicology187
Ch. 17Characterization of Epidermal Langerhans Cells207
Ch. 18Measuring and Quantifying Ultraviolet Radiation Exposures217
Ch. 19Animal Models for Phototoxicity Testing229
Ch. 20Photoirritation (Phototoxicity) Testing in Humans245
Ch. 21The Evaluation of Photoallergic Contact Sensitizers in Humans251
Ch. 22Chemical Leukoderma (Depigmentation)259
Ch. 23New Models to Assess In Vitro Action of Retinoids271
Ch. 24Sample Protocols for Carcinogenesis and Photocarcinogenesis281
Ch. 25Testing for Reproductive Hazards from Dermal Exposure303
Ch. 26Quantitative Sensory Testing313
Ch. 27Alternative Methods in Dermatotoxicology319
Ch. 28Skin Equivalents to Measure Phototoxicity337
Ch. 29A Practical Process for Assessing the Validity of Alternative Methods for Toxicity Testing351
Ch. 30Update on Agency Initiatives in Alternative Methods377
Index383


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