Enzymology and Molecular Biology of Carbonyl Metabolism 7 Book

1	The Big Book of Aldehyde Dehydrogenase Sequences: An Overview of the Extended Family	1
2	Reaction-Chemistry-Directed Sequence Alignment of Aldehyde Dehydrogenases	9
3	Three-Dimensional Structure of Mitochondrial Aldehyde Dehydrogenase: Mechanistic Implications	15
4	A Structural Explanation for the Retinal Specificity of Class 1 ALDH Enzymes	27
5	Structure and Function of Betaine Aldehyde Dehydrogenase: An Enzyme within the Multienzyme Aldehyde Dehydrogenase System	39
6	Evaluation of the Roles of the Conserved Residues of Aldehyde Dehydrogenase	45
7	Aldehyde Dehydrogenase Catalytic Mechanism: A Proposal	53
8	Inhibition of Human Mitochondrial Aldehyde Dehydrogenase by Metabolites of Disulfiram and Structural Characterization of the Enzyme Adduct by HPLC-Tandem Mass Spectrometry	61
9	Mechanism of Inhibition of Rat Liver Class 2 ALDH by 4-Hydroxynonenal	71
10	Aldehyde Inhibitors of Aldehyde Dehydrogenases	79
11	Covalent Modification of Sheep Liver Cytosolic Aldehyde Dehydrogenase by the Oxidative Addition of Coloured Phenoxazine, Phenothiazine and Phenazine Derivatives	89
12	A Thioeater Analogue of an Amino Acctylenic Aldehyde Is a Suicide Inhibitor of Aldehyde Dehydrogenase and an Inducer of Apoptosis in Mouse Lymphoid Cells Overexpressing the bcl2 Gene	97
13	Reaction between Sheep Liver Mitochondrial Aldehyde Dehydrogenase and a Chromogenic 'Reporter Group' Reagent	107
14	Activity of the Human Aldehyde Dehydrogenase 2 Promoter Is Influenced by the Balance between Activation by Hepatocyte Nuclear Factor 4 and Repression by Perosixome Proliferator Activated Receptor [delta], Chicken Ovalbumin Upstream Promoter-Transcription Factor, and Apolipoprotein Regulatory Protein-1	115
15	[alpha],[beta]-Unsaturated Aldehydes Mediate Inducible Expression of Glutathione S-Transferase in Hepatoma Cells through Activation of the Antioxidant Response Element (ARE)	123
16	Effect of Arachidonic Acid Alone or with Prooxidant on Aldehyde Dehydrogenases in Hepatoma Cells	133
17	Prepubertal Regulation of the Rat Dioxin-Inducible Aldehyde Dehydrogenase (ALDH3)	143
18	Effects of Tamoxifen and Toremifene on ALDH1 and ALDH3 in Human Retinal Pigment Epithelial Cells and Rat Liver	151
19	Negative Regulation of Rat Hepatic Aldehyde Dehydrogenase 3 by Glucocorticoids	159
20	Modulation of Class 3 Aldehyde Dehydrogenase Gene Expression: An Eye Opening Experience	165
21	Susceptibility of Hepatoma Cells to Lipid Peroxidation and Adaptation of ALDH 3C Activity to Iron-Induced Oxidative Stress	171
22	The Lack of AHD4 Induction by TCDD in Corneal Cells May Involve Tissue-Specific Regulatory Proteins	181
23	Human Corneal and Lens Aldehyde Dehydrogenases: Localization and Function(s) of Ocular ALDH1 and ALDH3 Isozymes	189
24	The Role of Retinoid Metabolism by Alcohol and Aldehyde Dehydrogenases in Differentiation of Cultured Neuronal Cells	199
25	Metabolism of Retinaldehyde by Human Liver and Kidney	205
26	The Hunt for a Retinal-Specific Aldehyde Dehydrogenase in Sheep Liver	213
27	Cardiac Metabolism of Enals	223
28	Oxidation of Ethanol to Acetaldehyde in Brain and the Possible Behavioral Consequences	231
29	Cloning and Expression of a cDNA Encoding a Constitutively Expressed Rat Liver Cytosolic Aldehyde Dehydrogenase	237
30	The Roles of Acetaldehyde Dehydrogenases in Saccharomyces Cerevisiae	243
31	Characterization of an Aldehyde Dehydrogenase Gene Fragment from Mung Bean (Vigna radiata) Using the Polymerase Chain Reaction	249
32	Aldehyde Dehydrogenase Gene Superfamily: The 1998 Update	255
33	Human Alcohol Dehydrogenase Family: Functional Classification, Ethanol/Retinol Metabolism, and Medical Implications	265
34	Dynamics in Alcohol Dehydrogenase Elucidated from Crystallographic Investigations	275
35	Studies on Variants of Alcohol Dehydrogenases and Its Domains	285
36	Uncompetitive Inhibitors of Alcohol Dehydrogenases	295
37	Tandem Mass Spectrometry of Alcohol Dehydrogenase and Related Biomolecules	305
38	Function of Alcohol Dehydrogenase and Aldehyde Dehydrogenase Gene Families in Retinoid Signaling	311
39	Primary Role of Alcohol Dehydrogenase Pathway in Acute Ethanol-Induced Impairment of Protein Kinase C-Dependent Signaling System	321
40	Class II Alcohol Dehydrogenase: A Suggested Function in Aldehyde Reduction	331
41	Zinc Binding Characteristics of the Synthetic Peptide Corresponding to the Structural Zinc Site of Horse Liver Alcohol Dehydrogenase	339
42	Amphibian Alcohol Dehydrogenase: Purification and Characterization of Classes I and III from Rana perezi	343
43	Extracellular Acidification: A Novel Detection System for Ligand/Receptor Interactions: Demonstration with Bioactive Peptides and CHO or Pancreatic [beta] Cells, but of Possible Interest for Tracing Putative Receptors in Ethanol Metabolism	351
44	Multiplicity and Complexity of SDR and MDR Enzymes	359
45	Regulatory Factors and Motifs in SDR Enzymes	365
46	Bioinformatics in Studies of SDR and MDR Enzymes	373
47	The Protective Role of 11[beta]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase against Tobacco-Smoke Related Lung Cancer	379
48	Structure-Function Relationships of 3[beta]-Hydroxysteroid Dehydrogenases Involved in Bile Acid Metabolism	389
49	Cloning and Sequencing of a New Comamonas testosteroni Gene Encoding 3[alpha]-Hydroxysteroid Dehydrogenase/Carbonyl Reductase	395
50	Comparative Properties of Three Pteridine Reductases	403
51	Effect of Androgen Structures on the Inhibition of Metyraponeinreductase in Rat, Mouse, and Human Liver	411
52	Physiological Relevance of Aldehyde Reductase and Aldose Reductase Gene Expression	419
53	The Aldo-Keto Reductases and Their Role in Cancer	427
54	Structure-Function Studies of FR-1: A Growth Factor-Inducible Aldo-Keto Reductase	435
55	4-Hydroxynonenal Metabolism by Aldo/Keto Reductase in Hepatoma Cells	445
56	Interconversion Pathways of Aldose Reductase Induced by Thiol Compounds	453
57	Aldo-Keto Reductases in Norepinephrine Metabolism	459
58	Rotamers of Tolrestat and Their Binding Mode to Aldose Reductase	465
59	Stereoselective High-Affinity Reduction of Ketonic Nortriptyline Metabolites and of Ketotifen by Aldo-Keto Reductases from Human Liver	473
60	Formation of Lens Aldose Reductase Mixed Disulfides with GSH by UV Irradiation and Its Proteolysis by Lens Calpain	481
61	Inhibition of Aldose Reductase by Gossypol and Gossypol-Related Compounds	487
62	Inhibition of Human Aldose and Aldehyde Reductases by Non-Steroidal Anti-Inflammatory Drugs	493
63	Regulation of Aldose Reductase by Aldehydes and Nitric Oxide	501
64	The Cytoxicity of Methylglyoxal and 3-Deoxyglucosone Is Decreased in the Aldehyde Reductase Gene-Transfected Cells	509
65	Enzymes Metabolizing Aldehydes in HL-60 Human Leukemic Cells	517
66	Rat Carbonyl Reductase: How Many Genes?	523
67	Cytostatic Drug Resistance: Role of Phase-I Daunorubicin Metabolism in Cancer Cells	529
68	Expression of mRNAs for Dihydrodiol Dehydrogenase Isoforms in Human Tissues	539
69	Alterations in the Expression of Daunorubicin Phase-I Metabolising Enzymes in Different Carcinoma Cell Lines	545
	Index	553