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The Use of Restricted Significance Tests in Clinical Trials Book

The Use of Restricted Significance Tests in Clinical Trials
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The Use of Restricted Significance Tests in Clinical Trials, This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved., The Use of Restricted Significance Tests in Clinical Trials
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  • The Use of Restricted Significance Tests in Clinical Trials
  • Written by author David S. Salsburg
  • Published by Springer-Verlag New York, LLC, 7/31/2012
  • This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved.
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Preface
Pt. 1 Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data
Ch. 1 The Randomized Controlled Clinical Trial 3
Ch. 2 Probability Models and Clinical Medicine 10
Ch. 3 Significance Tests Versus Hypothesis Tests 22
Ch. 4 Neyman's Insights 30
Ch. 5 Reconciling Fisher and Neyman 39
Pt. 2 Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials
Ch. 6 Continuous Measures Taken over Time 49
Ch. 7 Combining Data Across Measures 60
Ch. 8 Counts of Events 78
Ch. 9 Permutation Tests and Resampling Techniques 89
Ch. 10 Neyman's Restricted Chi Square Tests 97
Ch. 11 Miscellaneous Methods for Increasing Power 104
Ch. 12 Bayesian Estimation 115
Ch. 13 An Example of the Type of Analysis Suggested in This Book 126
References 161
Index 171


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The Use of Restricted Significance Tests in Clinical Trials, This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved., The Use of Restricted Significance Tests in Clinical Trials

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The Use of Restricted Significance Tests in Clinical Trials, This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved., The Use of Restricted Significance Tests in Clinical Trials

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The Use of Restricted Significance Tests in Clinical Trials, This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved., The Use of Restricted Significance Tests in Clinical Trials

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