Textbook of Hemophilia Book

1	Overview of hemostasis	1
2	Cellular processing of factors VIII and IX	5
3	Work-up of a bleeding adult	13
4	Molecular basis of hemophilia A	19
5	Hemophilia A : role of factor VIII in coagulation	27
6	Natural history of inhibitor development in children with severe hemophilia A treated with factor VIII products	34
7	Prophylaxis	39
8	Continuous infusion of coagulation products in hemophilia	46
9	Inhibitors to factor VIII - immunology	53
10	Inhibitors to factor VIII - molecular basis	59
11	Inhibitors to factor VIII - epidemiology and treatment	64
12	Inhibitors to factor VIII - mild and moderate hemophilia	71
13	Inhibitors to factor VIII/IX : treatment of inhibitors - immune tolerance induction	74
14	Inhibitors of factor VIII : treatment of acute bleeds	80
15	Acquired inhibitors to factor VIII	86
16	Hemophilia B - molecular basis	91
17	Inhibitors in hemophilia B	97
18	Treatment of inhibitors in hemophilia B	101
19	Pharmacokinetics	106
20	Work-up of a bleeding child	112
21	Care of the child with hemophilia	120
22	The neonate with hemophilia	125
23	Products used to treat hemophilia : evolution of treatment for hemophilia A and B	131
24	Products used to treat hemophilia : recombinant products	136
25	Products used to treat hemophilia : plasma-derived coagulation factor concentrates	142
26	Products used to treat hemophilia : recombinant factor VIIa	147
27	Products used to treat hemophilia : dosing	153
28	Products used to treat hemophilia : regulation	158
29	Joint replacement	164
30	Synoviorthesis in hemophilia	169
31	Pseudotumors in patients with hemophilia	174
32	Radiology	177
33	Magnetic resonance imaging/joint outcome assessment	182
34	Physiotherapy in the management of hemophilia	193
35	Transfusion transmitted disease : history of epidemics (focus on HIV)	200
36	Transfusion transmitted disease : hepatitis C virus infection and liver transplantation	207
37	Gene therapy : introduction and overview	214
38	Gene therapy for hemophilia B	220
39	Gene therapy for hemophilia A	226
40	Gene therapy : molecular engineering of factor VIII and factor IX	229
41	Laboratory assays in hemophilia	235
42	Standardization of assays	242
43	Obstetrics and gynecology : hemophilia	249
44	von Willebrand disease : molecular aspects	257
45	von Willebrand disease : epidemiology	265
46	von Willebrand disease : biological diagnosis	272
47	Classification and clinical aspects of von Willebrand disease	279
48	Treatment of von Willebrand disease : desmopressin	285
49	Treatment of von Willebrand disease : therapeutic concentrates	289
50	Women and von Willebrand disease	296
51	Factor II	302
52	Factor V and combined factor V and VIII deficiencies	306
53	Congenital factor VII deficiency	311
54	Factor X and factor X deficiency	315
55	Factor XI deficiency	321
56	Factor XIII	328
57	Fibrinogen	332
58	Miscellaneous rare bleeding disorders	338
59	Quality of life in hemophilia	345
60	The economics of hemophilia treatments	351
61	Comprehensive care and delivery of care : the developed world	359
62	Comprehensive care and delivery of care : the developing world	366
63	Comprehensive care and delivery of care : the global perspective	371