Dendritic Cells in Cancer Book

1 The Central Role of Dendritic Cells in Immunity Jessica Chu Russell D. Salter 1

2 Dendritic Cells in Cancer: Emergence of the Discipline Michael R. Shurin Michael T. Lotze 11

Part I Alterations of the Dendritic Cell System in Cancer

3 Tumor-Infiltrating Dendritic Cells: The Pathologist's Perspective Dmitry W. Gutkin 33

4 Functional Defects of Dendritic Cells in Cancer Mikhail M. Dikov Irina S. Chekneva 57

5 General Properties of Dendritic Cell Populations in Cancer Benjamin J. Daniel Duane P. Jeansonne Suzanne R. Thibodeaux Tyler J. Curiel 77

6 Elimination of Dendritic Cells in Cancer Viktor Umansky Dirk Schadendorf 89

Part II Mechanisms of Dendritic Cell Dysfunction in Cancer

7 Tumor-Derived Factors Responsible for Dendritic Cell Dysfunction Alberto Pinzon-Charry J. Alejandro López 103

8 Tumor-Derived Exosomes as Dendritic Cell Modulators Roberta Valenti Veronica Huber Paola Filipazzi Manuela Iero Giorgio Parmiani Licia Rivoltini 119

9 Signaling Pathways Mediating Dendritic Cell Dysfunction in Cancer Jing Yang Qing Yi 129

10 A Role for STAT3 in Dendritic Cell Regulation by Tumor-Derived Factors Dmitry I. Gabrilovich 143

11 Tumor-Associated Inflammation and Impact on Dendritic Cell Function Zoltan Pos Marianna Sabatino Tara Spivey Hui Liu Andras Falus Francesco M. Marincola 157

12 Changes in Dendritic Cells in Cancer and Aging Annabelle Grolleau-Julius Raymond L. Yung 171

13 Stress, Immunity and Dendritic Cells in Cancer Rachel Kohman Alexander W. Kusnecov 181

14 Cancer Therapy and Dendritic Cell Immunomodulation Galina V. Shurin Neil Amina Michael R. Shurin 201

Part III Role of Dendritic Cells in Tumor Escape

15 Role of IDO in DendriticCell Differentiation and Function in Cancer Alexey Popov Joachim L. Schultze 219

16 Dendritic Cells: From Inducers of Specific T-Cell Responses to Promoters of Angiogenesis George Coukos Fabian Benencia 231

17 Protumorigenic Function of Dendritic Cells Anjli Kukreja 243

18 Dendritic Cell Maturation Versus Polarization in Tumor Escape Michael W. Lipscomb Walter J. Storkus Amy K. Wesa 257

Part IV Dendritic Cells in Cancer: Clinical Aspects

19 Trafficking of Dendritic Cells in the Tumor Environment Zoya R. Yurkovetsky Ghena N. Yurkovetsky 271

20 Dendritic Cells in Tumor-Draining Lymph Nodes Alistair J. Cochran Rong-Rong Huang Eijun Itakura Jonathan H. Lee Barbara G. Molenkamp 291

21 Dendritic Cell Vaccines in Cancer: Obstacles to Overcome Ezra D. Mirvish Rebecca G. Pomerantz Louis D. Falo Larisa J. Geskin 309

22 How Best to Generate Dendritic Cells from Patients with Cancer and How Best to Use them for Immunotherapeutic Purposes Mark M. Aloysius Richard A. Robins Oleg Eremin 331

23 Genetically Modified Dendritic Cells in Cancer Immunotherapy Brian J. Morrison Jason C. Steel Melissa Gregory John C. Morris Anatoli M. Malyguine 347

24 Dendritic Cell Tumors Lourdes R. Ylagan 365

25 Future Directions in Dendritic Cell Research in Cancer Madhav V. Dhodapkar 375

Index 385