Cell Stress Proteins Book

Foreword     ix
Acknowledgement     xi
List of Contributors     xiii
Introduction: Heat Shock Proteins-From Drosophila Stress Proteins to Mediators of Human Disease   Stuart K. Calderwood     1
Stress Response and Molecular Chaperones     5
Biology of the Heat Shock Response and Stress Conditioning   George A. Perdrizet   Michael J. Rewinski   Emily J. Noonan   Lawrence E. Hightower     7
Bacterial Stress Sensors   Wolfgang Schumann     36
Unfolded Protein Response: Contributions to Development and Disease   Nan Liao   Linda M. Hendershot     57
Molecular Mechanisms of Stress Protein Expression     89
Genetic Models of HSF Function   Andras Orosz   Ivor J. Benjamin     91
HSF1 and HSP Gene Regulation   Richard Voellmy     122
Cellular Stress Proteins     141
Small Heat Shock Proteins in Physiological and Stress-Related Processes   Diana Orejuela   Anne Bergeron   Genevieve Morrow   Robert M. Tanguay     143
Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy   Xiang-Yang Wang   Douglas P. Easton   John R.Subjeck     178
Molecular Chaperones and Protein Folding     207
Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors   Robert T. Youker   Jeffrey L. Brodsky     209
Protein Disassembly by Hsp40-Hsp70   Samuel J. Landry     228
Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol   Kazutoyo Terada   Masataka Mori     255
Role of Molecular Chaperones in Cell Regulation     279
FKBP Co-Chaperones in Steroid Receptor Complexes   Joyce Cheung-Flynn   Sean P. Place   Marc B. Cox   Viravan Prapapanich   David F. Smith     281
Up and Down: Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP   Shu-Bing Qian   Cam Patterson     313
Role of Cdc37 in Protein Kinase Folding   Atin K. Mandal   Devi M. Nair   Avrom J. Caplan     326
Intracellular and Extracellular Stress Proteins in Human Disease     339
Targeting Hsp90 in Cancer and Neurodegenerative Disease   Len Neckers   Percy Ivy     341
gp96 and Tumor Immunity: A Simple Matter of Cross-Presentation Antigens?   Christopher V. Nicchitta     364
Immunoregulatory Activities of Extracellular Stress Proteins    A. Graham Pockley   Munitta Muthana     377
Heat Shock Proteins and Neurodegenerative Diseases   Ian R. Brown     396
Heat Shock Proteins in the Progression of Cancer   Stuart K. Calderwood   Abdul Khalique   Daniel R. Ciocca     422
Index     451