Particle-Lung Interactions, Second Edition (Lung Biology in Health and Disease) Book

Introduction Claude Lenfant vii

Preface ix

Contributors xiii

Part 1 Structure and Function of the Lung

1 Functional Aspects of Lung Structure as Related to Interaction with Particles Christian Mühlfeld Matthias Ochs 1

Part 2 Particle Characteristics

2 Ambient Tropospheric Particles Paul A. Solomon Daniel L. Costa 17

3 Manufactured Nanoparticles Robert N. Grass Ludwig K. Limbach Wendelin J. Stark 38

4 Particulate Carriers for Pulmonary Drug Delivery Stephanie Hein Andreas Henning Michael Bur Marc Schneider Claus-Michael Lehr 60

Part 3 Inhalation of Particles

5 Deposition, Retention and Clearance, and Translocation of Inhaled Fine and Nano-Sized Particles in the Respiratory Tract Winfried Möller Wolfgang G. Kreyling Otmar Schmid Manuela Semmler-Behnke Holger Schulz 79

Part 4 Health Effects of Particle Inhalation

6 The Epidemiology of Particle Health Effects Joel Schwartz 108

7 Cardiovascular Consequences of Particles Mark W. Frampton Mark J. Utell Jonathan M. Samet 120

8 Autonomic Mediation of the Cardiac Responses to Particle Exposure Beatriz Gonzalez-Flecha 137

9 Effects of Airborne Particles on Respiratory Viral Infection Ilona Jaspers Katherine Horvath 151

10 Airborne Particles and Structural Remodeling of the Lungs Amy K. Madl Christopher Carosino Kent E. Pinkerton 167

Part 5 Cellular and Molecular Mechanisms of Particle Health Effects

11 Effect of Particles on Mucus and Mucociliary Clearance Malcolm King 193

12 The Role of Surfactant in Particle Exposure Francis H. Y. Green Samuel Schürch Matthias Amrein Peter J. Gerber Zoya Leonenko 204

13 Nanoparticle-Cell Membrane Interactions Barbara Rothen-Rutishauser Fabian Blank ChristianMühlfeld Peter Gehr 226

14 Mechanisms and Processes Underlying Toxicological Responses to Particles Vicki Stone Ken Donaldson 243

15 Aeroallergen-Lung Interactions Carsten Schleh Jens M. Hohlfeld 266

16 Dose-Response Relationships Tobias Stoeger Otmar Schmid 288

Index 305