Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders Book

Part 1 Introduction: Basic Mechanisms of Neurodegeneration.

1 Introduction to Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders (Dennis Dickson).

2 Cell Death and Neurodegeneration (Violetta N. Pivtoraiko and Kevin A. Roth).

3 Oxidative Stress and Balance in Neurodegenerative Diseases (George Perry, Siddhartha Mondragón-Rodríguez, Akihiko Nunomura, Xiongwei Zhu, Paula I. Moreira and Mark A. Smith).

4 Protein Aggregation in Neurodegeneration (Adriano Aguzzi and Veronika Kana).

5 Protein Degradation in Neurodegeneration: The Ubiquitin Pathway (Lynn Bedford, Robert Layfield, Nooshin Rezvani, Simon Paine, James Lowe and R. John Mayer).

6 Genetics of Neurodegeneration (John Hardy).

7 Transgenic Animal Models of Proteinopathies (Naruhiko Sahara, Heather Melrose, Simon D’Alton and Jada Lewis).

Part 2 Alzheimer’s Disease and Aging.

8 Clinical Aspects of Alzheimer’s Disease (David Knopman).

9 Genetics of Alzheimer’s Disease (Lars Bertram and Rudolph E. Tanzi).

10 Neuropathology of Alzheimer’s Disease and its Variants (Charles Duyckaerts and Dennis Dickson).

11 Aß Amyloid Production (Colin L. Masters and Konrad Beyreuther).

12 Elimination of Amyloid-ß from the Brain, its Failure in Alzheimer’s Disease and Implications for Therapy (Roy O. Weller, Seth Love and James A.R. Nicoll).

Part 3 Tauopathies.

13 Introduction to the Tauopathies (Michel Goedert).

14 Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 (Bernardino Ghetti, Zbigniew K. Wszolek, Bradley F. Boeve, Salvatore Spina and Michel Goedert).

15 Progressive Supranuclear Palsy and Corticobasal Degeneration (Dennis Dickson, Jean-Jaques Hauw, Yves Agid and Irene Litvan).

16 Pick’s Disease (David G. Munoz, Huw R. Morris and Martin Rossor).

17 Argyrophilic Grain Disease (Markus Tolnay and Heiko Braak).

18 Parkinsonism–Dementia Complex of Guam (Kiyomitsu Oyanagi, Tomoyo Hashimoto and Mineo Yamazaki).

19 Postencephalitic Parkinsonism (Kurt A. Jellinger).

Part 4 Synucleinopathies.

20 Introduction to [alpha]–Synucleinopathies (Maria Grazia Spillantini).

21 Parkinson’s Disease (Kurt A. Jellinger).

22 Dementia with Lewy Bodies and Parkinson’s Disease Dementia (Paul G. Ince).

23 Lewy Bodies in Conditions other than Disorders of [alpha]-Synuclein (Coro Paisán-Ruiz, Laura Parkkinen and Tamas Revesz).

24 Multiple System Atrophy (Janice L. Holton, Andrew J. Lees and Tamas Revesz).

Part 5 Trinucleotide Repeat Disorders.

25 Introduction to Trinucleotide Repeat Diseases (H. Brent Clark).

26 Huntington’s Disease (John C. Hedreen and Raymund A.C. Roos).

27 Spinocerebellar Ataxias (Hidehiro Mizusawa, H. Brent Clark and Arnulf H. Koeppen).

28 Friedreich’s Ataxia (Arnulf H. Koeppen).

29 Dentatorubral-pallidoluysian Atrophy (Hitoshi Takahashi, Mitsunori Yamada and Shoji Tsuji).

30 Spinal and Bulbar Muscular Atrophy (Gen Sobue, Hiroaki Adachi and Masahisa Katsuno).

Part 6 Prion Disorders.

31 Introduction to Prion Disorders (Adriano Aguzzi and Veronika Kana).

32 Sporadic Creutzfeldt–Jakob Disease (Herbert Budka, Mark W. Head, James W. Ironside, Pierluigi Gambetti, Piero Parchi and Fabrizio Tagliavini).

33 Genetic Creutzfeldt–Jakob Disease (Piero Parchi, Pierluigi Gambetti and Sabina Capellari).

34 Fatal Familial and Sporadic Insomnia (Piero Parchi, Sabina Capellari and Pierluigi Gambetti).

35 A New Prion Disease: Protease-Sensitive Prionopathy (Pierluigi Gambetti, Gianfranco Puoti, Qingzhong Kong and Wenquan Zou).

36 Variant Creutzfeldt–Jakob Disease (James W. Ironside, Mark W. Head and Robert G. Will).

37 Gerstmann–Sträussler–Scheinker Disease (Bernardino Ghetti, Fabrizio Tagliavini, Gabor Kovacs and Pedro Piccardo).

38 Kuru (Catriona Ann McLean).

39 Iatrogenic Creutzfeldt–Jakob Disease (James W. Ironside, Richard S.G. Knight and Mark W. Head).

Part 7 Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis/Motor Neuron Disease.

40 Introduction (James Lowe).

41 Frontotemporal Lobar Degeneration with TDP-43 Pathology (Ian R.A. Mackenzie and Manuela Neumann).

42 Neuronal Intermediate Filament Inclusion Disease (Nigel J. Cairns).

43 Frontotemporal Lobar Degeneration with FUS Immunoreactive Inclusions (Manuela Neumann and Ian R.A. Mackenzie).

44 Amyotrophic Lateral Sclerosis, Primary Lateral Sclerosis and Spinal Muscular Atrophy (Michael J. Strong, Tibor Hortobágyi, Koichi Okamoto and Shinsuke Kato).

Part 8 Other Neurodegenerative Disorders.

45 Introduction: Genetic Analysis as a Lumper and Splitter in Neurodegenerative Disease (John E. Duda).

46 Inherited Amyloidoses and Neurodegeneration: Familial British Dementia and Familial Danish Dementia (Tamas Revesz, Agueda Rostagno, Gordon Plant, Tammaryn Lashley, Blas Frangione, Jorge Ghiso and Janice L. Holton).

47 Neurodegeneration with Brain Iron Accumulation (John E. Duda and Kurt A. Jellinger).

48 Familial Encephalopathy with Neuroserpin Inclusion Bodies (Richard L. Davis).

49 Hereditary Ferritinopathies (Ruben Vidal, Marie Bernadette Delisle, Olivier Rascol and Bernardino Ghetti).