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Preface.
Introduction.
1 What is Parkinson’s disease? From pathophysiology to symptoms (Andreas Hartmann, Yves Agid, Anthony Schapira).
I. Pathophysiology of Parkinson’s disease.
1. Dysfunctions of the main neuronal pathways in Parkinson’s disease.
a. An overview of neuronal systems affected in Parkinson’s disease.
b. Dopaminergic neurons.
c. Non-dopaminergic neurons.
2. Consequences of dopaminergic neuronal lesions on basal ganglia circuits.
a. The dopaminergic nigrostriatal system: pre- and postsynaptic compensatory mechanisms.
b. Pathologic alterations of nigrostriatal circuits in Parkinson’s disease.
3. Histopathology of Parkinson’s disease.
4. The etiopathogenesis of Parkinson’s disease.
a. The genetics of Parkinson’s disease: any clues for the sporadic forms?
b. Relevant environmental factors: focus on mitochondria.
c. Mechanisms of cell death in Parkinson’s disease: therapeutic implications.
5. Conclusions.
a. Parkinson’s disease or Parkinson’s syndromes?
b. What Parkinson’s disease is not.
II. Clinical features of Parkinson’s disease.
1. Motor symptoms.
2. Non-motor symptoms.
a. Depression.
b. Apathy.
c. Cognitive impairment.
d. Sleep.
e. Autonomic dysfunction.
f. Sensory symptoms.
3. The different forms of Parkinson’s disease: relevance for prognosis.
4. The differential diagnosis of Parkinson’s disease.
5. Treatment-related symptoms.
a. Motor complications.
b. Non-motor complications.
2 Treatment of Parkinson’s disease (Anthony Schapira, Andreas Hartmann, Yves Agid).
I. Antiparkinsonian agents.
1. Levodopa.
2. COMT inhibitors.
3. Dopamine agonists.
4. Monoamine oxidase B inhibitors.
5. Other drugs.
II. Medical management.
1. Initiation of treatment.
2. Maintenance of treatment (Fig. 2.7).
3. Motor complications.
4. Management of non-motor complications.
III. Non-medical management.
1. Surgery.
2. Destructive lesions.
3. Cell therapy.
4. Growth factors.
IV. Neuroprotection.
1. MAO-B inhibitors.
2. Dopamine agonists.
3. Coenzyme Q.
4. Creatine.
5. Antiapoptotic drugs.
V. Conclusion.
3 Case studies.
Case studies—diagnostic index.
Index.
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| $99.99 | Digital |
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Tom Edwards
reviewed Parkinsonian Disorders in Clinical Practice on September 21, 2020
Parkinsonian Disorders in Clinical Practice
Disturbingly simple depiction of the mind. Johnson is unquestionably in awe of the brain. His awe seems to have impaired his skepticism. The result is that he sensationalized what he learned and at times provided absolutely false information as if it were fact.
For example, He is under the assumption that the better people are at reading emotions, the more extroverted. Where is the evidence for such an absurd claim? This is why extraverts often misdiagnose introverts with autism, when in fact they are not even on the spectrum. Worse, despite being around some of the most respected neuroscientists the world has to offer, he was still holding tight to the myth that people only use 10% of their brains. It's absurd. These are only two examples of the many. He really didn't have a good enough grasp of neuroscience to write this book. Some journalists and science writers can swing it, but he is not nearly skeptical enough to pull it off.
The book's target audience seems to be those who also have no education in the neurosciences. Sadly, those people will believe what he is saying because he included work from very respected researchers who have conducted some pretty good studies. He related their work as well as many of his own assumptions. The very way in which he ties together the bits of information he gleaned from the researchers really demonstrates his lack of understanding. For him to have written a book to educate others seems grossly irresponsible. I would highly suggest finding an introductory book written by an actual scientist instead.
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Add Parkinsonian Disorders in Clinical Practice, This book gives the reader an up-to-date, clear and logical idea of what caring for parkinsonian patients entails - a challenge that clinicians will face for many years to come. It is split into three sections: Section 1: A compilation of the major bra, Parkinsonian Disorders in Clinical Practice to your collection on WonderClub |