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Introduction | ||
What is clinical pharmacology? | ||
1 | Clinical pharmacokinetics | 1 |
General overview of pharmacokinetics | 2 | |
Pharmacokinetics | 4 | |
Drug clearance | 6 | |
Volume of distribution | 8 | |
The half-life | 10 | |
Oral availability | 12 | |
Protein binding | 14 | |
pH and pharmacokinetics | 16 | |
2 | Factors affecting dosing | 19 |
Drug metabolism | 20 | |
Saturable metabolism | 22 | |
Pharmacogenetics | 24 | |
Dosing in liver disease and other disease states | 26 | |
Renal drug elimination | 28 | |
Dosing in renal impairment | 30 | |
Dosing in the elderly | 32 | |
Dosing in children | 34 | |
Drugs in pregnancy | 36 | |
Drugs in human milk | 38 | |
3 | Altered drug effect | 41 |
Adverse drug reactions | 42 | |
Drug-induced allergy | 44 | |
Adverse drug events | 46 | |
Preventing adverse drug events | 48 | |
Drug/drug interactions | 50 | |
Inducers of drug metabolism/inhibitors of drug metabolism | 52 | |
Drug/food interactions | 54 | |
4 | Pharmacovigilance | 57 |
Drug development | 58 | |
Therapeutic drug monitoring (TDM) | 60 | |
Drugs involved in therapeutic drug monitoring | 62 | |
Overdose/poisoning | 64 | |
Common poisonings | 66 | |
Pharmacological aspects of drug dependence | 68 | |
5 | Optimal therapeutics | 71 |
Principles of drug action | 72 | |
Applied pharmacology | 74 | |
Compliance with medication | 76 | |
Principles of therapeutics | 78 | |
Patients and their drugs | 80 | |
The drug profile | 82 | |
Evidence-based medicine | 84 | |
Pharmacoeconomics | 86 | |
Drug information/resources | 88 | |
6 | Appendix | 91 |
Important equations in pharmacology | 92 | |
The pharmacokinetic triangle | 93 | |
Glossary/abbreviations | 94 | |
Test questions | 96 | |
Test answers | 98 | |
Index | 101 |
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