Asymmetric Synthesis of Natural Products Book

	Preface
	List of Common Abbreviations
1	Introduction	1
1.1	Some Properties of Natural Products	4
1.2	Natural Products as Drugs	7
1.3	Structures of Natural Products	11
1.4	Synthesis of Natural Products	16
2	Chirality, Topology and Asymmetric Synthesis	18
2.1	The Need for Enantiopure Compounds	28
2.2	Determination of Enantiomeric Purity	32
2.3	Chirality and Thermodynamic Principles of Asymmetric Induction	34
2.4	Methods for Obtaining Chiral Compounds	37
3	Asymmetric Synthesis	46
3.1	Allylic Strain	47
3.2	Reactions of the Carbonyl Group	49
3.3	Reactions of Olefins	78
4	Carbohydrates	94
4.1	Monosaccharides	95
4.2	Polysaccharides	102
4.3	Glycoproteins and Proteoglycans	106
4.4	Glycolipids	107
4.5	Sugar Antibiotics	108
4.6	Cyclitols	110
5	Amino Acids, Peptides and Proteins	116
5.3	Enzymes and Receptors	123
5.4	Clinical Modification of Peptides	125
5.5	Biosynthesis of Amino Acids	125
5.6	Asymmetric Synthesis of Amino Acids	131
6	Nucleosides, Nucleotides and Nucleic Acids	147
7	Polyketides	153
7.1	Biosynthesis	154
7.2	Fatty Acids	155
7.3	Polypropionates: Polyether Antibiotics	159
7.4	Aromatic Polyketides	166
8	Isoprenoids	168
8.1	Terpenoids	169
8.2	Carotenoids	179
8.3	Steroids	181
9	Shikimic Acid Derivatives	192
10	Alkaloids	196
10.1	Heterocyclic Alkaloids	196
10.2	Alkaloids with an Exocyclic Nitrogen	216
10.3	Polyamine Alkaloids	218
10.4	Peptide Alkaloids	218
10.5	Terpene Alkaloids	219
	Subject Index	223
	Index of Compounds	230