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Organic Synthesis: The Disconnection Approach Book

Organic Synthesis: The Disconnection Approach
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Organic Synthesis: The Disconnection Approach, One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to th, Organic Synthesis: The Disconnection Approach
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  • Organic Synthesis: The Disconnection Approach
  • Written by author Stuart Warren
  • Published by Wiley, John & Sons, Incorporated, 8/24/2011
  • One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to th
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Authors

1. Introduction: Planning Organic Syntheses..

2. Synthons and Reagents: Aromatic Compounds.

3. Strategy I: The Order of Events.

4. One-Group C-X Disconnections.

5. Chemoselectivity.

6. Two-Group C-X Disconnections.

7. Strategy III.

8. Amine Synthesis.

9. Protecting Groups.

10. One Group C-C Disconnections I: Alcohols.

11. General Strategy A: Choosing Disconnections.

12. Stereoselectivity A.

13. One Group C-C Disconnections II: Carbonyl Compounds.

14. Regioselectivity.

15. Alkene Synthesis.

16. Strategy VII: Use of Acetylenes.

17. Diels-Alder.

18. Strategy VIII: Carbonyl Condensations.

19. 1,3-diCO Compounds.

20. Control in C=O Condensations.

21. 1,5-diCO Compounds.

22. Nitro Groups.

23. 1,2-diCO Compounds.

24. Radicals.

25. 1,4-diCO Compounds.

26. Reconnection.

27. 1,6-diCO Compounds.

28. Strategy of C=O Disconnections.

29. Saturated Heterocycles.

30. Cyclopropanes.

31. Rearrangements.

32. Four-Membered Rings.

33. Ketenes.

34. Five-Membered Rings.

35. Pericyclic Reactions.

36. Six-Membered Rings.

37. Strategy of Ring Synthesis.

38. Stereoselectivity B.

39. Aromatic Heterocycles.

40: Advanced Strategy.


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Organic Synthesis: The Disconnection Approach, One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to th, Organic Synthesis: The Disconnection Approach

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Organic Synthesis: The Disconnection Approach, One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to th, Organic Synthesis: The Disconnection Approach

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Organic Synthesis: The Disconnection Approach, One approach to organic synthesis is retrosynthetic analysis. With this approach a chemist will start with the structure of their target molecule and progressively cut bonds to create simpler molecules. Reversing this process gives a synthetic route to th, Organic Synthesis: The Disconnection Approach

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