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This volume represents the proceedings of the third in a series of annual inter national symposia. The first, The Neuroregulation of Autonomic, Endocrine, and Immune Systems, was held in Indianapolis in the fall of 1985. The second, Psychological and Biological Approaches to the Understanding of Human Disease, was held in Bielefeld, Germany in the fall of 1986. The theme of this series concerns the communication between the central nervous system and the other major systems of the body, and the purpose is to monitor the frontiers of research into these neuronal/hormonal regulatory interactions and their application to medicine. The present volume deals with the role of peptides and amino acids in these information transfer processes. Great strides have been made in exploring the important role of amino acids and pep tides in neuroregulation, and the ongoing biotechnology revolution promises signi ficant scientific and medical advances throughout the next decade and beyond. The work described in this volume captures the great excitement and pro mise of this biomedical renaissance. This meeting was cosponsored by Searle/ Monsanto and Washington University and held in St. Louis in the early fall of 1986. A major contributor to these proceedings was Dr. Thomas O'Donohue whose chapter deals with his work in characterizing the endogenous ligands for the PCP and sigma opioid receptors. Tom's personality and career personi fied the dedication of this series to the principle of a broad multidisciplinary approach to scientific problems."
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reviewed Neurobiology of Amino Acids, Peptides and Trophic Factors on March 24, 2017
Neurobiology of Amino Acids
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The good:
- bold theorizing! But testable and falsifiable, so it has more merit than technically savvy sci-fi. (still, all it changes is the mechanism. It doesn't address the selection pressures, why intelligence, or many of the objections he raises to a darwinian account)
- many important and fascinating experiments are described
- even if you don't buy his theory you will learn a lot of interesting facts about genetics and epigenetics, the technical level is high and, especially in the last couple of parts, very satisfying.
- Fills a niche, not a lot of interesting material on the subject that's available to the general reader.
The bad:
- didn't make it clear to me why his evolutionary stories were more plausible and useful than all the ones he dismisses (even tho I find his exercises in making alternate accounts pedagogically useful)
- Apparently the discovery of fire and heat-preparation of food was not an event worth mentioning, even tho this is interpreted as causing the shortening of our intestines which lead to much better energy utilization (the intestines need a lot of energy to do their work), freeing up resources for a power-hungry organ like the brain
- although he did make a point of the importance of brain plasticity, he never really addresses the long developmental time of human children and the extent of dendritic pruning that takes place during this period. Having a longer window for critical and sensitive periods sounds like an important factor in how much culture can change an organism.
- his discussion of how traits like intelligence or musicality (or indeed a brain region specific to written language) was useless to our pre-historic forefathers wasn't entirely convincing (what good is a cubic-root to a caveman? I'm not sure, but pattern recognition and being able to think and manipulate abstractions in some capacity sounds like it could be useful? It does sound like it's a subject that has been covered by others, so I should perhaps not hold it against him for not dedicating more time to the subject). (hide spoiler)]
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