Modern Therapeutics in Rheumatic Disease Book

	Preface
	List of Contributors
I	Rheumatoid Arthritis
1	New Treatment Opportunities for Rheumatoid Arthritis	3
2	Genetic Influences on Treatment Response in Rheumatoid Arthritis	11
3	Nonsteroidal Anti-Inflammatory Drugs in the Treatment of Rheumatoid Arthritis	23
4	Additional Considerations on the Use of Nonsteroidal Anti-Inflammatory Drugs	47
5	Glucocorticoid Therapy in Rheumatoid Arthritis	65
6	Anti-Tumor Necrosis Factor Agents	89
7	Interleukin-1 Receptor Antagonist Treatment in Rheumatoid Arthritis	109
8	Leflunomide: An Immunomodulatory Drug for the Treatment of Rheumatoid Arthritis	121
9	Matrix Metalloproteinase Inhibitors as Therapies for Rheumatoid Arthritis	135
10	Combination Disease-Modifying Anti-Rheumatic Drug (DMARD) Therapy	147
11	Experimental Therapeutics for Rheumatoid Arthritis	159
II	Osteoarthritis
12	Slow-Acting Drugs for the Treatment of Osteoarthritis	179
13	Intra-Articular Therapy in Osteoarthritis	193
14	Promoting Articular Cartilage Repair	201
15	Using Molecular Markers to Monitor Osteoarthritis	215
16	New Therapeutic Targets for Osteoarthritis: The Rewards of Research	237
17	Recent Developments in the Therapy of Osteoarthritis	253
III	Systemic Autoimmune Diseases
18	Treatment of Systemic Lupus Erythematosus	259
19	Treatment of the Antiphospholipid Syndrome	297
20	Treatment of Systemic Lupus Erythematosus by Blocking T-Cell Costimulation	315
21	Current Management of Systemic Sclerosis	323
22	Sjogren's Syndrome	337
23	Mixed Connective Tissue Disease	347
24	Vasculitis	359
25	Treatment of Juvenile Rheumatoid Arthritis	389
26	Treatment of Inflammatory Myopathies	415
27	Psoriatic Arthritis	435
28	Complement Inhibitors in Rheumatic Diseases	443
29	Hematopoietic Stem Cell Transplantation of Autoimmune Disease	453
IV	Gene Therapy in Rheumatic Diseases
30	Vectors for Gene Delivery	479
31	Gene Targeting of Cytokines and the Mitogen-Activated Protein Kinase Pathways in Human Rheumatoid Synovium Using the Severe Combined Immunodeficiency Mouse Model	505
32	Retroviral Transduction of Antigen-Specific CD4+T Cells for Local Delivery of Regulatory Molecules	521
33	Gene Transfer to Lymphocytes Targeting Cartilaginous Collagen Type II	535
34	Gene Therapy in Murine Arthritis: Cytokine-Directed Targeting	549
35	Modulation of the IkB Kinase/Nuclear Factor-kB Pathway by Gene Therapy	565
36	Regulation of Apoptosis in Rheumatoid Synoviocytes	575
37	Gene Therapy for Arthritis: Conception, Consolidation, and Clinical Trial	583
V	Other Rheumatic Disorders
38	Recent Advances in the Pharmacotherapy of Spondyloarthropathies	595
39	Modern Therapy of Crystal Arthropathies	605
40	Treatment of Musculoskeletal Infections	621
	Index	639