Glutamate and Addiction Book

	Preface
	Contributors
I	Introduction: Physiology and Pharmacology of Glutamate
1	Molecular Pharmacology and Physiology of Glutamate Receptors	3
2	Pharmacology of Glutamate Receptors	23
3	Glutamate and Neurotoxicity	51
4	Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity	63
5	Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia	71
II	Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine)
6	Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity	83
7	Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization	107
8	Addiction and Glutamate-Dependent Plasticity	127
9	Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving	143
10	Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication	157
11	Glutamate Neurotransmission in the Course of Cocaine Addiction	171
12	Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs	183
13	Roles of Glutamate, Nitric Oxide, Oxidative Stress, and Apoptosis in the Neurotoxicity of Methamphetamine	201
14	Methamphetamine Toxicity: Roles for Glutamate, Oxidative Processes, and Metabolic Stress	211
15	Nitric Oxide-Dependent Processes in the Action of Psychostimulants	229
16	Effects of Novel NMDA/Glycine-Site Antagonists on the Blockade of Cocaine-Induced Behavioral Toxicity in Mice	243
17	Clinical Studies Using NMDA Receptor Antagonists in Cocaine and Opioid Dependence	261
18	The Role of mGluR5 in the Effects of Cocaine: Implications for Medication Development	271
III	Glutamate and Opiate Drugs (Heroin) of Abuse
19	Role of the Glutamatergic System in Opioid Tolerance and Dependence: Effects of NMDA Receptor Antagonists	281
20	The Role of NMDA Receptors in Opiate Tolerance, Sensitization, and Physical Dependence: A Review of the Research, A Cellular Model, and Implications for the Treatment of Pain and Addiction	295
21	Modification of Conditioned Reward by N-Methyl-D-aspartate Receptor Antagonists	323
22	Morphine Withdrawal as a State of Glutamate Hyperactivity: The Effects of Glutamate Receptor Subtype Ligands on Morphine Withdrawal Symptoms	329
IV	Glutamate and Alcohol Abuse and Alcoholism
23	Alcohol Actions on Glutamate Receptors	343
24	Glutamate and Alcohol-Induced Neurotoxicity	357
25	Role of Glutamate in Alcohol Withdrawal Kindling	375
26	Alcohol and Glutamate Neurotransmission in Humans: Implications for Reward, Dependence, and Treatment	389
27	Mechanism of Action of Acamprosate Focusing on the Glutamatergic System	399
28	The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance	409
29	Overview of Clinical Studies for Acamprosate	417
	Index	427