The IGF System, Vol. 17 Book

	Preface
	Contributors
1	Historical Perspective: The Origins and Development of the Somatomedin Hypothesis	1
I	Molecular Biology of the IGF System
2	Molecular Biology of IGF-I and IGF-II	19
3	Regulation of IGF Gene Expression	37
4	Molecular Biology of the Type 1 IGF Receptor	63
5	Molecular Biology of the IGF-II/Mannose-6-Phosphate Receptor	89
6	Molecular Biology of the IGF Binding Proteins	111
II	Biological Actions of the IGFs
7	IGF-I Receptor Function: Transducing the IGF-I Signal into Intracellular Events	143
8	Type 2 IGF Receptor-Mediated Events	165
9	Alternative IGF-Related Receptors	199
10	IGF Binding Proteins as Modulators of IGF Action	227
11	IGF-Independent Actions of the IGF Binding Proteins	257
12	IGF Binding Proteins and Extracellular Matrix	273
13	Biological Actions of Proteolytic Fragments of the IGF Binding Proteins	281
14	The IGF Binding Protein Superfamily	315
15	IGFs and Cell Growth	329
16	Posttranslational Modification of the IGF Binding Proteins	355
III	IGF Physiology
17	IGFs in the Female Reproductive System	379
18	The IGF Axis in the Male Reproductive System	407
19	IGFs and the Nervous System	425
20	IGF System Components and Their Role in Bone Metabolism	457
21	IGFs and Skeletal Muscle	497
22	IGFs and the Digestive Tract	517
23	Actions of IGF System Proteins from Studies of Transgenic and Gene Knockout Models	545
IV	Clinical Aspects of the IGFs
24	Metabolic Effects of IGFs	577
25	Clinical Uses of IGF-I and IGF Binding Protein Assays	617
26	IGF Binding Protein Proteolysis in Various Clinical States	633
27	IGF Deficiency	651
28	Tumor Hypoglycemia Linked to IGF-II	675
29	IGFs in the Evaluation of Acromegaly	699
30	IGF in the Treatment of Diabetes	721
31	IGF-I Treatment of Growth Hormone Insensitivity	739
	Index	771