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Cytokine knockouts Book

Cytokine knockouts
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  • Cytokine knockouts
  • Written by author Scott K. Durum and Kathrin Muegge; foreword by Klaus Rajewsky
  • Published by Totowa, N.J. : Humana Press, c1998., 1997/12/08
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Authors

Foreword
Preface
Contributors
List of Color Plates
Ch. 1 The IL-2 Deficiency Syndrome: A Lethal Disease Caused by Abnormal Lymphocyte Survival 1
Ch. 2 IL-7 Knockout Mice and the Generation of Lymphocytes 21
Ch. 3 Lymphoid Development and Function in IL-7R-Deficient Mice 37
Ch. 4 CD40 Ligand Knockout Mice 53
Ch. 5 Physiological, Immunological, and Pathological Functions of Tumor Necrosis Factor (TNF) Revealed by TNF Receptor-Deficient Mice 69
Ch. 6 Cooperation Between the TNF Receptors Demonstrated by TNF Receptor Knockout Mice 89
Ch. 7 Immunodeficiency of Tumor Necrosis Factor and Lymphotoxin-[alpha] Double-Deficient Mice 103
Ch. 8 Characterization of Lymphotoxin-[alpha]-Deficient Mice 119
Ch. 9 Interleukin-1[beta]-Deficient Mice 129
Ch. 10 Functional Phenotype of Mice Deficient in the IL-1R Type 1 Gene: A Comparison with Other Genetically Modified Mice 155
Ch. 11 Mice Deficient in Interleukin-1[beta] Converting Enzyme 173
Ch. 12 Neutrophilia and B-Cell Plasmacytosis in Mice Lacking the Murine IL-8 Receptor Homolog 189
Ch. 13 Knockouts of Interferons, Interferon Receptors and Interferon Signaling Components 207
Ch. 14 IL-6 Gene Knockout Mice 227
Ch. 15 IL-6 Unique Functions in Inflammation, Bone Metabolism, and B-Cell Neoplasias Revealed by Studies on IL-6 Deficient Mice 237
Ch. 16 Myocardial, Hematological, and Placental Disorders Caused by Targeted Disruption of gp130, A Common Signal Transducer for IL-6 Family of Cytokines 259
Ch. 17 NF-IL6 Knockout Mice 287
Ch. 18 Disruption of the LIF Receptor 315
Ch. 19 Phenotypes of TGF[beta] Knockout Mice 335
Ch. 20 The Transforming Growth Factor-[beta]1 Knockout Mouse: The Phenotype and Its Implications for TGF[beta]1 Function 369
Ch. 21 Granulocyte-Macrophage Colony-Stimulation Factor (GM-CSF)-Deficient Mice 401
Ch. 22 The In Vivo Role of the Receptors for IL-3, GM-CSF, and IL-5 [actual symbol not reproducible] 419
Ch. 23 Granulocyte Colony-Stimulating Factor (G-CSF)-Deficient Mice 435
Ch. 24 Reduction of Platelets and Megakaryocytes in c-mpl-Deficient Mice 457
Index 467


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