Thrombosis and Hemorrhage Book

	Preface
	Acknowledgments
	Contributors
Sect. 1	Coagulation and Fibrinolysis
1	Coagulation Cascade: An Overview	1
2	Molecular Genetics of Blood Coagulation	22
3	Regulation of Coagulation	35
4	The Tissue Factor Pathway of Coagulation	62
5	Fibrin Formation and Stabilization	81
6	Regulation of Fibrinolysis	105
Sect. 2	Platelets
7	Regulation of Megakaryopoiesis	120
8	Platelet Morphology and Shape Change	140
9	Platelet Membranes and Receptors	161
10	Mechanisms of Platelet Activation	187
Sect. 3	Vessel Wall
11	The Endothelium in Thrombosis and Hemorrhage	206
12	Angiogenesis and Hemostasis	220
13	Vascular Response to Injury	236
14	Von Willebrand Factor	246
15	Interactions of Coagulation and Fibrinolytic Proteins with the Vessel Wall	266
16	Endothelium-derived Vasoactive Factors	278
17	Rheology	294
Sect. 4	Clinical Approach to Bleeding and Thrombosis
18	Approach to Bleeding	315
19	Approach to Thrombosis	330
20	Assessment of Peripheral Arterial and Venous Thrombosis	343
21	Laboratory Methods in Hemostasis	363
Sect. 5	Quantitative Platelet Disorders
22	Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome	424
23	Alloimmune Thrombocytopenias	441
24	Drug-induced Thrombocytopenias	457
25	Immune Thrombocytopenic Purpura	476
26	Thrombocytosis	496
Sect. 6	Qualitative Platelet Disorders
27	Congenital Disorders of Platelet Function	507
28	Acquired Disorders of Platelet Function	525
Sect. 7	Disorders of Coagulation Factors and Fibrinolysis
29	Von Willebrand Disease	539
30	Hemophilia - Factor VIII Deficiency	560
31	Other Coagulation Factor Deficiencies	575
32	Factor VIII and Other Coagulation Factor Inhibitors	599
33	Antiphospholipid Syndrome and Lupus Anticoagulants	611
Sect. 8	Thrombotic Disorders
34	The Relationship Between Thrombosis and Atherosclerosis	628
35	Inherited and Acquired Hypercoagulable States	648
36	Clinical Manifestations of Endothelial Dysfunction	685
Sect. 9	Other Disorders of Hemostasis
37	Less Common Thrombotic and Embolic Disorders	707
38	Vascular Purpura and Diseases of Blood Vessels	763
39	Disseminated Intravascular Coagulation	781
40	Coagulopathy of Liver Failure and Vitamin K Deficiency	803
41	Maternal Hemostasis: Coagulation Problems of Pregnancy	816
42	Hemorrhage, Thrombosis, and Antithrombotic Therapy in Children	840
43	Interaction of Blood and Artificial Surfaces	865
Sect. 10	Management of Bleeding
44	Platelet Transfusion Therapy	886
45	Plasma and Component Therapy	897
46	Nontransfusional Hemostatic Agents	915
Sect. 11	Management of Thrombosis
47	Pharmacology of Antiplatelet Agents	929
48	Pharmacology of Heparin-related Compounds and Coumarin Derivations	939
49	The Pharmacology of Thrombolytic Agents	949
50	New Antithrombotic Strategies	978
51	Bleeding Complications of Antithrombotic Therapy	996
52	Antithrombotic Interventions in Cerebrovascular Disease	1003
53	Antithrombotic Therapy in Ischemic Heart Disease	1030
54	Antithrombotic Therapy in Peripheral Vascular Disease	1053
55	Anticoagulants in Atrial Fibrillation	1066
56	Prevention and Treatment of Venous Thromboembolic Disease	1077
57	Gene Therapy of Thrombotic and Hemorrhagic Disorders	1096
	Index	1109