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Preface iii
Contributors vii
Perspectives Clete A. Kushida 1
Features, Factors, and Characteristics
History Michael Zupancic Peretz Lavie 11
Epidemiology Kin M. Yuen 27
Ontogeny Timothy F. Hoban Donald L. Bliwise 39
Phylogeny and Animal Models: An Uninhibited Survey Todd D. Morgan John E. Remmers 61
Upper Airway Anatomy Avery Tung 81
Physiology and Dynamics of the Upper Airway Jingtao Huang Carole L. Marcus 93
Upper Airway Pathology John G. Park Teofilo Lee-Chiong 111
Control of Breathing in Sleep Curtis A. Smith Jerome A. Dempsey Steven R. Barczi Ailiang Xie 125
Arousal from Sleep Peter Halasz 149
Pathogenesis Anh Tu Duy Nguyen Susie Yim Atul Malhotra 171
Risk Factors Kannan Ramar Christian Guilleminault 197
Familial and Genetic Factors Sanjay R. Patel Peter V. Tishler 223
The Spectrum ofSleep-Disordered Breathing Adnan Habib Barbara Phillips 245
Associations and Consequences
Morbidity and Mortality Christine Won Dominique Robert 259
Central and Autonomic Nervous Systems Ian M. Colrain John Trinder 275
Cardiac Arrhythmias and Congestive Heart Failure Sheree Chen T. Douglas Bradley 293
Hypertension and the Cardiovascular System Rohit Budhiraja Stuart F. Quan 323
Endocrine Function and Glucose Metabolism Katherine Stamatakis Naresh M. Punjabi 337
Obesity Mark Eric Dyken Mohsin Ali Shekar Raman Kim E. Eppen 355
Mood and Behavior Mark S. Aloia Amanda Schurle Bruce 377
Sleepiness Douglas B. Kirsch Ronald D. Chervin 393
Health-Related Quality-of-Life Cheryl A. Moyer Jeffrey S. Moyer Ronald D. Chervin 425
Driving Risk and Accidents Patricia Sagaspe Pierre Philip 443
Economic and Societal Impact Valerie Wittmann Daniel O. Rodenstein 451
Index 473
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