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Pt. I Computational Approaches
Ch. 1 Web Resources for Protein Analysis Stephen A. Cammer Cammer, Stephen A. Michael Czar Czar, Michael 3
Ch. 2 Artificial Neural Networks for Therapeutic Protein Engineering James Lara Lara, James 23
Ch. 3 Phylogenetics and Medicinal Protein Engineering Michael Anthony Purdy Purdy, Michael Anthony 57
Ch. 4 Clustering and Classification Approaches to Identifying Protein Properties Lilia Milkova Ganova-Raeva Ganova-Raeva, Lilia Milkova Zoya Emilova Dimitrova Dimitrova, Zoya Emilova 79
Ch. 5 Analysis of Coordinated Substitutions in Proteins David Campo Campo, David 107
Pt. II Protein Engineering Targets: Vaccine
Ch. 6 Tuning the Immune Response to Our Advantage: Design of Vaccines with Tailored Functions Till A. Rohn Rohn, Till A. Martin F. Bachmann Bachmann, Martin F. 123
Ch. 7 Modification of HIV-1 Envelope Glycoprotein to Enhance Immunogenicity Michael Aidoo Aidoo, Michael Salvatore Butera Butera, Salvatore Dennis Ellenberger Ellenberger, Dennis 143
Ch. 8 Engineering Better Influenza Vaccines: Traditional and New Approaches Peter M. Pushko Pushko, Peter M. Rick A. Bright Bright, Rick A. Terrence M. Tumpey Tumpey, Terrence M. Gale E. Smith Smith, Gale E. 169
Ch. 9 Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers Paul Pumpens Pumpens, Paul Rainer G. Ulrich Ulrich, Rainer G. Kestutis Sasnauskas Sasnauskas, Kestutis Andris Kazaks Kazaks, Andris Velta Ose Ose, Velta Elmars Grens Grens, Elmars 205
Ch. 10 Polyomavirus-Derived Virus-Like Particles Rainer G. Ulrich Ulrich, Rainer G. Alma Gedvilaite Gedvilaite, Alma Tatyana Voronkova Voronkova, Tatyana AndrisKazaks Kazaks, Andris Kestutis Sasnauskas Sasnauskas, Kestutis Reimar Johne Johne, Reimar 249
Ch. 11 Papillomavirus-Derived Virus-Like Particles Andris Kazaks Kazaks, Andris Tatyana Voronkova Voronkova, Tatyana 277
Ch. 12 Recombinant Vaccines Against Hepatitis Viruses Jonny Yokosawa Yokosawa, Jonny Nestor O. Perez Perez, Nestor O. Livia M. G. Rossi Rossi, Livia M. G. 299
Pt. III Protein Engineering Targets: Diagnostics and Therapy
Ch. 13 Designer Diagnostic Reagents and Allergens Anna Obriadina Obriadina, Anna 319
Ch. 14 Peptide-Based Diagnostic Assays Maria J. Gomara Gomara, Maria J. Isabel Haro Haro, Isabel 333
Ch. 15 Recombinant Antibodies Alla Likhacheva Likhacheva, Alla Tatyana Ulanova Ulanova, Tatyana 353
Ch. 16 Protein Engineering for HIV Therapeutics James M. Smith Smith, James M. Dennis Ellenberger Ellenberger, Dennis Salvatore Butera Butera, Salvatore 385
Ch. 17 Recombinant Enzymes with New and Improved Properties Lilia M. Ganova-Raeva Ganova-Raeva, Lilia M. 407
Pt. IV Special Expression Systems
Ch. 18 Production of Pharmaceutical Compounds in Plants Miguel Angel Gomez Lim Lim, Miguel Angel Gomez 445
Ch. 19 Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins Andris Zeltins Zeltins, Andris 481
Ch. 20 Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents Anna Zajakina Zajakina, Anna Baiba Niedre-Otomere Niedre-Otomere, Baiba Ekaterina Alekseeva Alekseeva, Ekaterina Tatyana Kozlovska Kozlovska, Tatyana 519
Index 551
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