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Delivery Strategies for Antisense Oligonucleotide Therapeutics Book

Delivery Strategies for Antisense Oligonucleotide Therapeutics
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Delivery Strategies for Antisense Oligonucleotide Therapeutics, With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving b, Delivery Strategies for Antisense Oligonucleotide Therapeutics
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  • Delivery Strategies for Antisense Oligonucleotide Therapeutics
  • Written by author Saghir Akhtar
  • Published by CRC Press Inc, 1995/06/26
  • With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving b
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Preface
Ch. 1 Disrupting the flow of genetic information with antisense oligodeoxynucleotides: Research and Therapeutic Applications 1
Ch. 2 Cellular Delivery of Ribozymes 17
Ch. 3 Improved structural design and cellular uptake of triplex-forming oligonucleotides 39
Ch. 4 Pharmacokinetics and delivery of oligonucleotides to the brain 61
Ch. 5 In vivo pharmacokinetics of oligonucleotides following administration by different routes 71
Ch. 6 Nuclease-resistant DNA therapeutics 85
Ch. 7 Self-stabilized oligonucleotides as novel antisense agents 105
Ch. 8 Circular oligonucleotides as potential modulators of gene expression 123
Ch. 9 Peptide nucleic acids as antisense therapeutic agents 151
Ch. 10 Stabilized RNA analogs for antisense and ribozyme applications 161
Ch. 11 Uptake and localization of phosphodiester and chimeric oligodeoxynucleotides in normal and leukemic primary cells 177
Ch. 12 Oligonucleotide transport across membranes and into cells: effects of chemical modifications 191
Ch. 13 Liposomes as a delivery system for antisense and ribozyme compounds 199
Ch. 14 Intracellular delivery of oligonucleotides with cationic liposomes 223
Ch. 15 The delivery of oligonucleotides using pH-sensitive liposomes 233
Ch. 16 Enhancing endosomal exit of nucleic acids using pH-sensitive viral fusion peptides 247
Ch. 17 Targeted delivery of anti-hepatitis B antisense oligonucleotides 267
Ch. 18 Design, synthesis, and cellular delivery of antibody-antisense oligonucleotide conjugates for cancer therapy 283
Index 295


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Delivery Strategies for Antisense Oligonucleotide Therapeutics, With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving b, Delivery Strategies for Antisense Oligonucleotide Therapeutics

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