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Camptothecins: New Anti-Cancer Agents Book

Camptothecins: New Anti-Cancer Agents
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Camptothecins: New Anti-Cancer Agents, This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigge, Camptothecins: New Anti-Cancer Agents
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Digital Copy
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  • Camptothecins: New Anti-Cancer Agents
  • Written by author Milan Potmesil, Herbert M. Pinedo
  • Published by CRC Press Inc, 1994/12/19
  • This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigge
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Introduction 1
Ch. 1 Biochemistry of Camptothecin 9
Ch. 2 Camptothecin and Analogs: From Discovery to Clinic 21
Ch. 3 Twenty Years Later: Review of Clinical Trials with Camptothecin Sodium (NSC-100880) 43
Ch. 4 Preclinical Development of 20 (S)-Camptothecin, 9-Aminocamptothecin and Other Analogs 51
Ch. 5 Phase I Clinical Trial and Pharmacokinetic Results with Oral Administration of 20(S)-Camptothecin
Ch. 6 Clinical Studies of CPT-11 in Japan 67
Ch. 7 Clinical Trials and Pharmacokinetic Studies of CPT-11 in the United States 75
Ch. 8 Clinical Trials and Pharmacology Studies of CPT-11 and its Active Metabolite SN-38 in France: Preliminary Pharmacokinetic-Pharmacodynamic Relationships
Ch. 9 Topotecan Clinical Trials in the United States 93
Ch. 10 Clinical Trials of Topotecan in Europe
Ch. 11 Camptothecins: Dose-Limiting Toxicities and Their Management 113
Ch. 12 Cellular Determinants of Sensitivity and Resistance to Camptothecins 123
Ch. 13 The Perspectives 139
Index 143


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Camptothecins: New Anti-Cancer Agents, This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigge, Camptothecins: New Anti-Cancer Agents

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Camptothecins: New Anti-Cancer Agents, This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigge, Camptothecins: New Anti-Cancer Agents

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Camptothecins: New Anti-Cancer Agents, This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigge, Camptothecins: New Anti-Cancer Agents

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