Pharmaceutical statistics Book

	Preface
1	Basic Definitions and Concepts	1
2	Data Graphics	31
3	Introduction to Probability: The Binomial and Normal Probability Distributions	49
4	Choosing Samples	82
5	Statistical Inference: Estimation and Hypothesis Testing	96
6	Sample Size and Power	151
7	Linear Regression and Correlation	173
8	Analysis of Variance	215
9	Factorial Designs	265
10	Transformations and Outliers	289
11	Experimental Design in Clinical Trials	311
12	Quality Control	373
13	Validation	416
14	Computer Intensive Methods	437
15	Nonparametric Methods	464
16	Optimization Techniques and Screening Designs	506
	Glossary	540
App. I	Some Properties of the Variance	542
App. II	Comparison of Slopes and Testing of Linearity: Determination of Relative Potency	545
App. III	Multiple Regression	551
	App. IV: Tables	557
App. V	Outlier Tests and Chemical Assays	578
App. VI	Should a Single Unexplained Failing Assay Be Reason to Reject a Batch?	585
App. VII	When it is Appropriate to Average and its Relationship to the Barr Decision	594
App. VIII	Excel Workbooks and SAS Programs	599
App. IX	An Alternative Solution to the Distribution of the Individual Bioequivalence Metric	711
	Answers to Exercises	722
	Index	743