The Endothelium in Clinical Practice Book

The Endothelium as the Source of Novel Therapies

Prostacyclin (Prostaglandin I2) and Atherosclerosis, Karsten Schrör Prostacyclin and Thromboxane: Role in Ischemic Heart Disease, Jawahar L. Mehta and Baichun C. Yang Clinical Use of Prostacyclins, John A. Dormandy and Glyn Belcher Nitric Oxide Synthases: Enzymology and Mechanism-Based Inhibitors, John F. Parkinson and Gary Phillips Endothelin: From Basic to Pathophysiological Research, Katsutoshi Goto Transmigration of Leukocytes, B. Stein, Y. Khew-Goodall, J. Gamble, and M. A. Vadas Transforming Growth Factor-b and Cardiovascular Protection, David J. Grainger and James C. Metcalfe Coagulation Factors, Michael Kalafatis, Jack O. Egan, and Kenneth G. Mann

The Endothelium as a Target for Novel Therapies

Endothelial Dysfunction and Vascular Disease, Paul M. Vanhoutte, Louis Perrault, and Jean Paul Vilaine Complement and Endothelium: Novel Complement-Inhibitory Therapeutics, Una S. Ryan The Receptor for Advanced Gycation Endproducts: Implications for the, Development of Diabetic Vascular Disease, Osamu Hori, Shi Du Yan, and Ann Marie Schmidt Hypertension, Pierre Moreau and Thomas F. Lüscher Arterial Restenosis, Michael A. Reidy and Stephen M. Schwartz Pathobiology and Clinical Consequences of Plaque Rupture, Richard Gallo, Juan J. Badimon, James H. Chesebro, Valentin Fuster, and Lina Badimon Isoprostanes and Antioxidant Therapy in Human Diseases, Emma A. Meagher and Garrett A. FitzGerald Vasculoprotection by Estrogen Contributes to Gender Difference in Cardiovascular Diseases: Potential Mechanism and Role of Endothelium, Katalin Kauser and Gabor M. Rubanyi Lipoprotein(a): Insights from Transgenic Mice, Steven D. Hughes and Edward M. Rubin

Gene Therapy

Gene Therapy with Vascular Endothelial Growth Factor, Jeffrey M. Isner Vascular Disease and the Prospect of Gene Therapy, Heiko E. von der Leyen and Victor J. Dzau