Statistical Methods for Pharmaceutical Research Planning, Vol. 67 Book

	Preface	iii
1.	Quantitative Structure-Activity Relationships (QSAR)	1
1.1.	Introduction	1
1.2.	Regression and Related Methods	11
1.3.	Classification	42
1.4.	Miscellaneous	61
	References	89
2.	Screening Procedures for Discovering Active Compounds	105
2.1.	Introduction	105
2.2.	Formulation of the Problem	112
2.3.	The OC Curve and the Average Sample Number	114
2.4.	Procedures for Limiting Misclassification Errors	118
2.5.	Procedures for Maximizing Benefits Subject to a Constraint	121
2.6.	Procedures for Maximizing Net Financial Benefits	127
	References	136
3.	Allocation of Resources Between Related Screens	141
3.1.	Introduction	141
3.2.	Resource Allocation Between Ordered Screens	141
3.3.	Optimal Sequencing of Screens	163
	References	166
4.	R&D Project Selection Methods	167
4.1.	Introduction	167
4.2.	Checklists and Profile Charts	179
4.3.	Scoring Indices	186
4.4.	Profitability Indices	191
4.5.	Integer and Linear Programming	200
4.6.	Stochastic Programming	209
4.7.	Other Integer and Linear Programming Techniques for Handling Uncertainty	216
4.8.	Dynamic Programming and Nonlinear Models	220
4.9.	RESPRO: An Interactive Model	229
4.10.	Multiobjective Models	235
	References	238
	Summary: State of the Art	247
	Index	251