Ocular Oncology Book

	Preface
	Contributors
1	Clinical Overview of Uveal Melanoma: Introduction to Tumors of the Eye	1
2	Clinical Overview: Retinoblastoma	19
3	Epidemiology of Uveal Melanoma: Patient Characteristics, Risk Factors, and Predisposing Elements	35
4	Epidemiology of Retinoblastoma	47
5	Genetics of Uveal Melanoma: Chromosomal Rearrangements and the Identification of Genes Involved in Tumorigenesis	63
6	Structural Alterations and Gene Expression in the Pathogenesis of Uveal Melanoma	81
7	A Cascade of Genomic Changes Leads to Retinoblastoma	103
8	The Role of the Retinoblastoma Protein in Health, Malignancy, and the Pathogenesis of Retinoblastoma	129
9	Biochemical Pathways: Differential Gene Expression and Cellular Pathways Determining Tumor Phenotype Comparison of Uveal Melanocytes and Uveal Melanoma Cells In Vitro	189
10	p53 and the Molecular Regulation of Cell Fate in Retinoblastoma	211
11	Immunology of Uveal Melanoma: Adaptive Antitumor Immunity and the Basis for Immunotherapy	231
12	Immunology of Uveal Melanoma: Immunosuppressive Factors and the Basis for Immunotherapy	255
13	Models of Uveal Melanoma: Characterization of Transgenic Mice and Other Animal Models for Melanoma	269
14	Using Retinoblastoma Models to Develop New Treatment: Vitamin D Analogues	297
15	Therapy of Uveal Melanoma: Methods and Risk Factors Associated with Treatment	321
16	The Treatment of Retinoblastoma	353
17	Clinical Trials in Uveal Melanoma: Patient Characteristics and the Treatment of Intraocular Tumors	377
18	Clinical Trials in Retinoblastoma	401
19	Pathology of Uveal Melanoma: Histological Parameters and Patient Prognosis	407
20	Retinoblastoma: Pathology and Prognosis	427
21	Molecular Genetics of Retinoblastoma	449
22	Genetically Engineered Mouse Models of Retinoblastoma	465
23	Treatment of Extraocular Retinoblastoma	489
	Index	499