Amyotrophic Lateral Sclerosis Book

1	History of ALS	1
2	Epidemiology of ALS	17
3	The pathology of amyotrophic lateral sclerosis	43
4	The causes of sporadic amyotrophic lateral sclerosis	81
5	ALS clinical motor signs and symptoms	99
6	Frontotemporal dysfunction in amyotrophic lateral sclerosis	117
7	Familial ALS and genetic approaches to ALS	141
8	Objective markers of upper and lower motor neuron dysfunction : electrophysiological studies and neuroimaging technologies	167
9	Classification, diagnosis, and presentation of diagnosis of ALS	201
10	Natural history and prognosis in amyotrophic lateral sclerosis	227
11	Specifying motor neuron identity in the developing spinal cord	257
12	Neurodegeneration in amyotrophic lateral sclerosis	279
13	Excitotoxicity	299
14	Superoxide dismutase, oxidative stress, and ALS	339
15	Neuronal and non-neuronal cell interactions in ALS	355
16	Apoptosis in amyotrophic lateral sclerosis	381
17	Cytoskeletal proteins in the pathogenesis of ALS	395
18	Role of mitochondria in motor neuron degeneration in ALS	417
19	Environmental toxicity and ALS : novel insights from an animal model of ALS-PDC	435
20	Genetic causes and predisposition	449
21	ALS : a protein aggregate disease?	465
22	Neuroinflammation	487
23	The potential of gene therapy for motor neuron diseases	505
24	Experimental models of motor neuron diseases	525
25	Screening for ALS drugs	551
26	Clinical trial methodology	583
27	The multidisciplinary care clinic : the principles and an international perspective
28	The ALS patient CARE program - North American patient CARE database
29	Symptomatic pharmacotherapy : bulbar and constitutional symptoms	649
30	ALS pharmacotherapy : riluzole and clinical trials	665
31	Rehabilitation	691
32	Nutritional treatment : theoretical and practical issues	721
33	Respiratory care in amyotrophic lateral sclerosis	737
34	Psychosocial care for patients with ALS and their caregivers	761
35	Palliative care at the end of life	783
36	Palliative care : family perspective	799
37	End-of-life decision making	811